ArticleFrontiers in cardiovascular medicine2022
The relationship between Type D personality with atherosclerotic plaque and cardiovascular events: The mediation effect of inflammation and kynurenine/tryptophan metabolism.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association of Type D Personality and Anatomical Complexity as Predictors of Long-Term Mortality in Coronary Artery Disease: A Retrospective Case Study Based on Hospital Records.Diseases (Basel, Switzerland) · 2026Article
- Comparative Analysis of the Association of Biomarkers of Endothelial Dysfunction and Systemic Inflammation in Patients with Coronary Artery Disease with the Presence/Absence of Personality Type D.Journal of clinical medicine · 2026Article
- Physician burnout and type D personality relate to pericoronary fat phenotype and role of sympathetic activation: a cross-sectional study.Scientific reports · 2026Article
- Metabolomic Biomarkers for Non-Invasive Diagnosis of Coronary Artery Disease and Obstructive Sleep Apnea Co-Occurrence.Nature and science of sleep · 2026Article
- Cardiovascular Diseases and Type D Personality: Systematic Review and Meta-Analysis of the Literature of the Last 10 Years.Life (Basel, Switzerland) · 2025Review
- Social inhibition in depressed patients is associated with an altered activation profile of the interleukin-6-inducible transcription factor STAT3.Brain, behavior, & immunity - health · 2025Article
- Association of type D personality with vascular health in adolescents.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Cardiovascular events and coronary plaque vulnerability are linked to Type D personality. However, the fundamental mechanism has not been clarified. Our study determined to illustrate whether inflammatory status in plasma, in combination with kynurenine pathway activity in Type D individuals, is associated with plaque vulnerability and cardiovascular events in patients with coronary artery disease (CAD). Materials and methods: The Type D personality of 177 CAD patients were evaluated. Plasma biomarkers of inflammation (TNF-α, IL-6, and hs-CRP) were measured and pooled into standardized sumscores. Tryptophan and kynurenine metabolites were measured, and the kynurenine/tryptophan ratio (KTR) was calculated. Plaque vulnerability was measured Results: Type D individuals exhibited elevated TNF-α ( Conclusion: These results demonstrated that the connection between Type D personality and poor cardiovascular outcomes in CAD patients can be mediated by pro-inflammatory biomarkers and KTR.
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