ArticleCerebral circulation - cognition and behavior2021
Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the "ZOOM@SVDs" study.
Article in Cerebral circulation - cognition and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Intracranial arterial calcification and cerebrovascular function in the general aging population - A 7T MRI Study.Cerebral circulation - cognition and behavior · 2026Article
- Relation between Cerebral Small Vessel Function at 7T MRI and Small Vessel Disease Burden in a General Aging Population.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Association between retinal microvasculature and cerebral small vessel function in type 2 diabetes: An ultrahigh field MRI study.Diabetes, obesity & metabolism · 2025Article
- Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study.Cerebral circulation - cognition and behavior · 2025Article
- Assessment of Small Vessel Function Using 7T MRI in Patients With Sporadic Cerebral Small Vessel Disease: The ZOOM@SVDs Study.Neurology · 2024Observational
- Editorial.Cerebral circulation - cognition and behavior · 2024Article
- Three-tiered EGFr domain risk stratification for individualized NOTCH3-small vessel disease prediction.Brain : a journal of neurology · 2023Article
- The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial.European stroke journal · 2023Article
- Disentangling the effects of Alzheimer's and small vessel disease on white matter fibre tracts.Brain : a journal of neurology · 2023Article
- Diagnosing vascular cognitive impairment: Current challenges and future perspectives.International journal of stroke : official journal of the International Stroke Society · 2023Review
- Advanced MRI in cerebral small vessel disease.International journal of stroke : official journal of the International Stroke Society · 2023Review
- Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease-related brain injury.Brain structure & function · 2022Article
- Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke.NeuroImage. Clinical · 2022Article
- Diffusion MRI harmonization enables joint-analysis of multicentre data of patients with cerebral small vessel disease.NeuroImage. Clinical · 2021Article
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Authors and funding
18 authors at 5 institutions in 3 countries.
Funding
Abstract
Background: Cerebral small vessel diseases (SVDs) are a major cause of stroke and dementia. Yet, specific treatment strategies are lacking in part because of a limited understanding of the underlying disease processes. There is therefore an urgent need to study SVDs at their core, the small vessels themselves. Objective: This paper presents the rationale and design of the ZOOM@SVDs study, which aims to establish measures of cerebral small vessel dysfunction on 7T MRI as novel disease markers of SVDs. Methods: ZOOM@SVDs is a prospective observational cohort study with two years follow-up. ZOOM@SVDs recruits participants with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL, Discussion: ZOOM@SVDs will deliver novel markers of cerebral small vessel function in patients with monogenic and sporadic forms of SVDs, and establish their relation with disease burden and progression. These small vessel markers can support etiological studies in SVDs and may serve as surrogate outcome measures in future clinical trials to show target engagement of drugs directed at the small vessels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.