Evidence map›Paper›PMID 36324707›Full record

ReviewCerebral circulation - cognition and behavior2021

Cerebrospinal fluid biomarkers and apolipoprotein E genotype in cerebral amyloid angiopathy. A narrative review.

Aikaterini Theodorou, Ioanna Tsantzali, Elisabeth Kapaki, Vasilios C Constantinides, Konstantinos Voumvourakis, Georgios Tsivgoulis, George P Paraskevas

Abstract readReview
In one paragraph

Review in Cerebral circulation - cognition and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. International journal of molecular sciences · 2025
    Article
  4. Editorial.Cerebral circulation - cognition and behavior · 2024
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aikaterini TheodorouSecond Department of Neurology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Ioanna TsantzaliSecond Department of Neurology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Elisabeth KapakiFirst Department of Neurology, National & Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.
Vasilios C ConstantinidesSecond Department of Neurology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Konstantinos VoumvourakisSecond Department of Neurology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Georgios TsivgoulisSecond Department of Neurology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
George P ParaskevasSecond Department of Neurology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sporadic cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease, characterized by the deposition of β-amyloid within the cortical and leptomeningeal blood vessel walls. It has attracted interest concerning new therapeutic perspectives. However, there are scarce data regarding the cerebrospinal fluid biomarkers (CSF) and genetic factors in sporadic CAA. In this narrative review, we investigated the literature regarding the cerebrospinal fluid core biomarkers profile of patients with probable or possible CAA and its subtype, the CAA- related inflammation (CAA-ri), taking into account the clinical and radiological characteristics of the patients. We also analyzed the Apolipoprotein E (APOE) genotype differentiations among the different subtypes of cerebral amyloid angiopathy. Our results demonstrate specific CSF patterns of β-amyloid (Aβ

Indexed as

APOE genotypeCAA-riCerebral amyloid angiopathyCerebrospinal fluid biomarkersCortical superficial siderosisMicrobleeds

Identifiers

PMID36324707
PMCPMC9616386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.