Evidence map›Paper›PMID 36324647›Full record

ArticleBiological psychiatry global open science2022

Common Genetic Variation and Age of Onset of Anorexia Nervosa.

Hunna J Watson, Laura M Thornton, Zeynep Yilmaz, Jessica H Baker, Jonathan R I Coleman, Roger A H Adan, Lars Alfredsson, Ole A Andreassen, Helga Ask, Wade H Berrettini and 167 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Eating Disorders and Parkinson's Disease-2: Genetic Epidemiology and Shared Genomics.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Utilising genomic association data for causal inference in anorexia nervosa.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Ovarian hormones and eating disorders.Frontiers in psychology · 2024
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

177 authors at 20 institutions in 20 countries.

Hunna J WatsonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Zeynep YilmazDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jessica H BakerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jonathan R I ColemanInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Roger A H AdanSahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Ole A AndreassenNORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Helga AskDepartment of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
Wade H BerrettiniDepartment of Psychiatry, Center for Neurobiology and Behavior, Philadelphia, Pennsylvania.
Michael BoehnkeDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan.
Ilka BoehmDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Claudette BoniINSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Katharina BuehrenDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Josef BulantDepartment of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Roland BurghardtDepartment of Child and Adolescent Psychiatry, Klinikum Frankfurt/Oder, Frankfurt, Germany.
Xiao ChangCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Sven CichonDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
Roger D ConeLife Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.
Philippe CourtetDepartment of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France.
Scott CrowDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
James J CrowleyDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Unna N DannerDepartment of Clinical Psychology, Faculty of Social Sciences, University Utrecht, Utrecht, the Netherlands.
Martina de ZwaanDepartment of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.
George DedoussisDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Janiece E DeSocioCollege of Nursing, Seattle University, Seattle, Washington.
Danielle M DickDepartment of Psychology, Commonwealth University, Richmond, Virginia.
Dimitris DikeosFirst Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.
Christian DinaL'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.
Srdjan DjurovicNORMENT Centre, Department of Clinical Science, University of Oslo, Oslo, Norway.
Monika Dmitrzak-WeglarzDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Elisa Docampo-MartinezBarcelona Institute of Science and Technology, Barcelona, Spain.
Philibert DuriezINSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Karin EgbertsDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Centre for Mental Health, Würzburg, Germany.
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Johan G ErikssonDepartment of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Geòrgia EscaramísBarcelona Institute of Science and Technology, Barcelona, Spain.
Tõnu EskoProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Xavier EstivillBarcelona Institute of Science and Technology, Barcelona, Spain.
Anne FarmerInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Fernando Fernández-ArandaDepartment of Psychiatry, University Hospital Bellvitge-IDIBELL and CIBEROBN, Barcelona, Spain.
Manfred M FichterDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
Manuel FöckerDepartment of Child and Adolescent Psychiatry, University Hospital Münster, Münster, Germany.
Lenka ForetovaInstitute of Neuroscience and Medicine, Research Center Jülich, Jülich, Germany.
Andreas J ForstnerInstitute of Neuroscience and Medicine, Research Center Jülich, Jülich, Germany.
Oleksandr FreiNORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Steven GallingerQIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Ina GieglingDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Johanna GiurannaDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Fragiskos GonidakisFirst Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.
Philip GorwoodINSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Mònica GratacòsBarcelona Institute of Science and Technology, Barcelona, Spain.
Sébastien GuillaumeQIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Yiran GuoCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Hakon HakonarsonDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Joanna HauserDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Alexandra HavdahlNic Waals Institute, Lovisenberg Diaconal Hospitaland, Oslo, Norway.
Johannes HebebrandDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sietske G HelderInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Stefan HermsInstitute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Beate Herpertz-DahlmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Wolfgang HerzogDepartment of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.
Anke HinneyNic Waals Institute, Lovisenberg Diaconal Hospitaland, Oslo, Norway.
Christopher HübelNational Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, United Kingdom.
James I HudsonBiological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, Massachusetts.
Hartmut ImgartEating Disorders Unit, Parklandklinik, Bad Wildungen, Germany.
Stephanie JamainInserm U955, Institut Mondor de recherches Biomédicales, Laboratoire, Neuro-Psychiatrie Translationnelle, and Fédération Hospitalo-Universitaire de Précision Médecine en Addictologie et Psychiatrie, University Paris-Est-Créteil, Créteil, France.
Vladimir JanoutFaculty of Health Sciences, Palacky University, Olomouc, Czech Republic.
Susana Jiménez-MurciaDepartment of Psychiatry, University Hospital Bellvitge-IDIBELL and CIBEROBN, Barcelona, Spain.
Ian R JonesNational Centre for Mental Health, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom.
Antonio JuliàRheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
Gursharan KalsiInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Deborah KaminskáDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Jaakko KaprioInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Leila KarhunenDivision of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden.
Martien J H KasBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, the Netherlands.
Pamela K KeelDepartment of Psychology, Florida State University, Tallahassee, Florida.
James L KennedyInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Anna Keski-RahkonenClinicum, Department of Public Health, University of Helsinki, Helsinki, Finland.
Kirsty KiezebrinkInstitute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.
Lars KlareskogDivision of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden.
Kelly L KlumpDepartment of Psychology, Michigan State University, Lansing, Michigan.
Gun Peggy S KnudsenDepartment of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
Maria C La ViaDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Stephanie Le HellardDepartment of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorders Research, University of Bergen, Bergen, Norway.
Marion LeboyerDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dong LiCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Lisa LilenfeldDepartment of Clinical Psychology, the Chicago School of Professional Psychology, Washington, DC.
Bochao LinBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, the Netherlands.
Jolanta LissowskaBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, the Netherlands.
Jurjen LuykxBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, the Netherlands.
Pierre MagistrettiDepartment of Psychiatry, University of Lausanne-University Hospital of Lausanne, Lausanne, Switzerland.
Mario MajNORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Sara MarsalInsideOut Institute for Eating Disorders, The Charles Perkins Centre, the University of Sydney, Sydney, New South Wales, Australia.
Christian R MarshallDepartment of Paediatric Laboratory Medicine, the Hospital for Sick Children, Toronto, Ontario, Canada.
Morten MattingsdalNORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Ingrid MeulenbeltDepartment of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.
Nadia MicaliDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Karen S MitchellWomen's Health Sciences Division, National Center for PTSD, Boston, Massachusetts.
Alessio Maria MonteleoneDepartment of Psychiatry, University of Campania "Luigi Vanvitelli," Naples, Italy.
Palmiero MonteleoneDepartment of Psychiatry, University of Lausanne-University Hospital of Lausanne, Lausanne, Switzerland.
Richard MyersHudsonAlpha Institute for Biotechnology, Huntsville, Alabama.
Marie NavratilovaDepartment of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Ionna NtallaDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Julie K O'TooleKartini Clinic, Portland, Oregon.
Roel A OphoffCenter for Neurobehavioral Genetics, University of California at Los Angeles, Los Angeles, California.
Leonid PadyukovDivision of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden.
Jacques PantelINSERM 1124, Université de Paris, Paris, France.
Hana PapežováEating Disorders Unit, Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Dalila PintoDivision of Psychiatric Genomics, Department of Psychiatry, and Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York.
Anu RaevuoriDepartment of Adolescent Psychiatry, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Nicolas RamozINSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Ted Reichborn-KjennerudInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Valdo RiccaDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Samuli RipattiProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Stephan RipkeProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Franziska RitschelDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Marion RobertsInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Alessandro RotondoClinicum, Department of Public Health, University of Helsinki, Helsinki, Finland.
Dan RujescuDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Filip RybakowskiDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
André ScheragInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany.
Stephen W SchererMcLaughlin Centre, University of Toronto, Toronto, Ontario, Canada.
Ulrike SchmidtDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Laura J ScottDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan.
Jochen SeitzDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Yasmina SilénClinicum, Department of Public Health, University of Helsinki, Helsinki, Finland.
Lenka ŠlachtováDepartment of Biochemistry and Molecular Biology, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic.
P Eline SlagboomDepartment of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.
Margarita C T Slof-Op 't LandtDepartment of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.
Agnieszka SlopienInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany.
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, the Reference Center for Asbestos Exposure and Health Risk Assessment, Lódź, Poland.
Alfonso TortorellaAdolescent Health Unit, Second Department of Pediatrics, Athens, Greece.
Federica TozziBrain Sciences Department, Stremble Ventures, Limassol, Cyprus.
Janet TreasureDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Artemis TsitsikaAdolescent Health Unit, Second Department of Pediatrics, Athens, Greece.
Marta Tyszkiewicz-NwaforDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Konstantinos TziouvasPediatric Intensive Care Unit, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.
Annemarie A van ElburgDepartment of Clinical Psychology, Faculty of Social Sciences, University Utrecht, Utrecht, the Netherlands.
Eric F van FurthDepartment of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.
Esther WaltonDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Elisabeth WidenDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Stephanie ZerwasDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Stephan ZipfelDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Andrew W BergenOregon Research Institute, Eugene, Oregon.
Joseph M BodenDepartment of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Harry BrandtThe Center for Eating Disorders at Sheppard Pratt, Baltimore, Maryland.
Steven CrawfordDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
Katherine A HalmiNew York Presbyterian Hospital-Westchester Division, Weill Cornell Medical College of Cornell University, White Plains, New York.
L John HorwoodDepartment of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Craig JohnsonEating Recovery Center, Denver, Colorado.
Allan S KaplanInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Walter H KayeDepartment of Psychiatry, University of California San Diego, San Diego, California.
James E MitchellDepartment of Psychiatry and Behavioral Science, School of Medicine and Health Sciences, University of North Dakota, Fargo, North Dakota.
Catherine M OlsenCancer Control Group, University of Queensland, Brisbane, Queensland, Australia.
John F PearsonBiostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Michael StroberSemel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California.
Thomas WergeDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
David C WhitemanQIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
D Blake WoodsideInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Scott GordonQIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Sarah MaguireInsideOut Institute for Eating Disorders, The Charles Perkins Centre, the University of Sydney, Sydney, New South Wales, Australia.
Janne T LarsenNational Centre for Register-based Research, Aarhus BSS, Aarhus, Denmark.
Richard ParkerQIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Liselotte V PetersenNational Centre for Register-based Research, Aarhus BSS, Aarhus, Denmark.
Jennifer JordanDepartment of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Martin KennedyPathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Tracey D WadeCollege of Education, Psychology and Social Work, Flinders University, Adelaide, South Australia, Australia.
Andreas BirgegårdDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nicholas G MartinQIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Preben Bo MortensenNational Centre for Register-based Research, Aarhus BSS, Aarhus, Denmark.
Gerome BreenInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
University of North Carolina at Chapel Hill · USInserm · FRPoznan University of Medical Sciences · PLThe University of Queensland · AUNational Health Service · GBNorwegian Institute of Public Health · NOOslo University Hospital · NOUniversity Medical Center Utrecht · NLChildren's Hospital of Philadelphia · USKing's College London · GBLeiden University Medical Center · NLUniversitat Pompeu Fabra · ESUniversity of Helsinki · FIUniversity of Otago · NZAarhus University · DKBroad Institute · USCharles University · CZKarolinska Institutet · SEKarolinska University Hospital · SERWTH Aachen University · DE

Funding

OCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment MechanismsR01MH110427 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWLEY, JAMES JOSEPH · 2016 to 2021
$3.0M
5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9M
1/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109528 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2016 to 2020
$2.5M
Shared Genetic and Environmental Risk Factors for Anorexia Nervosa and Obsessive-Compulsive Disorder in DenmarkK01MH109782 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YILMAZ, ZEYNEP · 2016 to 2019
$620k
Medical Research Council MR/L010305/1NIMH NIH HHS K01 MH109782NIMH NIH HHS R01 MH110427NIMH NIH HHS U01 MH109514NIMH NIH HHS U01 MH109528Wellcome Trust
6 · The paper itself

Abstract

Background: Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche. Methods: A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (<13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses. Results: Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (single nucleotide polymorphism- Conclusions: Our results provide evidence consistent with a common variant genetic basis for age of onset and implicate biological pathways regulating menarche and reproduction.

Indexed as

Age of onsetAnorexia nervosaEarly-onsetGenetic risk scoreGeneticsGWASMenarcheMendelian randomizationPuberty

Identifiers

PMID36324647
PMCPMC9616394
OpenAlexW3200584904

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