Evidence map›Paper›PMID 36324608›Full record

ArticleRegenerative biomaterials2022

Is polydopamine beneficial for cells on the modified surface?

Yue Yu, Xiuli Wang, Yi Zhu, Yingning He, Hongrui Xue, Jiandong Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
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  4. Regenerative biomaterials · 2026
    Article
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  20. Advances in Regulating Cellular Behavior Using Micropatterns.The Yale journal of biology and medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yue YuState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.
Xiuli WangState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.
Yi ZhuState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.
Yingning HeState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.
Hongrui XueState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.
Jiandong DingState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the pioneering work of Messersmith's group discovering that polydopamine (PDA) can serve to adhere to many types of materials, the PDA coating has, as a biomimetic approach, been widely used to enhance cell adhesion by surface modification to bind biologically active substances to a bioinert substrate. Nevertheless, it is unclear whether or not the PDA itself is beneficial for cells. Herein, we report that a PDA coating decreases viability of cells under normal culture and observation conditions. Such an inhibition effect was not caused by the free PDA or any inherent cytotoxicity of this chemical substance but a contact-dependent phenomenon. Human bone marrow mesenchymal stem cells were employed as the default cell type and tissue culture plates were used as the default substrate, although some other cell types and substrates were also examined to confirm the universality of such an 'abnormal' phenomenon of a superstar molecule. The viability of cells on the PDA coating exhibited time dependence, and the decreased cell viability during the normal observation time was found to come from the decrease of cell number instead of the decrease of average viability per cell. The PDA coating led to less cell global migration yet more local motility of cells. Based on the concept of 'background adhesion' of cells on a surface without significant motifs of specific cell adhesion, we supposed that cells adhered to the PDA coating better, which influenced mobility and eventually proliferation. Hence, the cell behaviors on the PDA coating are reasonable, albeit a bit complicated.

Indexed as

biomaterialcell viabilitypolydopaminepolymersurface modification

Identifiers

PMID36324608
PMCPMC9610633

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.