Evidence map›Paper›PMID 36324510›Full record

ArticleFrontiers in genetics2022

Genome-wide association study for systemic lupus erythematosus in an egyptian population.

Ashraf A Elghzaly, Celi Sun, Loren L Looger, Misa Hirose, Mohamed Salama, Noha M Khalil, Mervat Essam Behiry, Mohamed Tharwat Hegazy, Mohamed Ahmed Hussein, Mohamad Nabil Salem and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  6. AnGenes · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Ashraf A ElghzalyDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, El-Mansoura, Egypt.
Celi SunArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Loren L LoogerDepartment of Neurosciences, Howard Hughes Medical Institute, University of California, San Diego, San Diego, CA, United States.
Misa HiroseDivision of Genetics, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Mohamed SalamaInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo, Egypt.
Noha M KhalilRheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mervat Essam BehiryRheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed Tharwat HegazyRheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed Ahmed HusseinRheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamad Nabil SalemDepartment of Internal Medicine, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt.
Ehab EltorabyDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, El-Mansoura, Egypt.
Ziyad TawhidDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, El-Mansoura, Egypt.
Mona AlwasefyDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, El-Mansoura, Egypt.
Walaa AllamCenter for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Iman El-ShiekhCenter for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Menattallah ElserafyCenter for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Anwar AbdelnaserInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo, Egypt.
Sara HashishInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo, Egypt.
Nourhan SheblInstitute of Global Health and Human Ecology, The American University in Cairo, New Cairo, Egypt.
Abeer Abdelmonem ShahbaDepartment of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Amira ElgirbyDepartment of Internal Medicine, Faculty of Medicine, Alexandria University, Bab Sharqi, Egypt.
Amina HassabDepartment of Clinical Pathology, Faculty of Medicine, Alexandria University, Bab Sharqi, Egypt.
Khalida RefayDepartment of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hanan Mohamed El-TouchyDepartment of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ali YoussefDepartment of Rheumatology and Immunology, Faculty of Medicine, Benha University Hospital, Benha, Egypt.
Fatma ShabacyDepartment of Rheumatology and Immunology, Faculty of Medicine, Benha University Hospital, Benha, Egypt.
Abdelkader Ahmed HashimDepartment of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.
Asmaa AbdelzaherDepartment of Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt.
Emad AlshebiniDepartment of Internal Medicine, Faculty of Medicine, Menoufia University, Al Minufiyah, Egypt.
Dalia FayezRheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Samah A El-BakryRheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mona H ElzohriDepartment of Internal Medicine, Faculty of Medicine, Assiut University, Asyut, Egypt.
Eman Nagiub AbdelsalamDepartment of Clinical Pathology, Faculty of Medicine, Assiut University, Asyut, Egypt.
Sherif F El-KhamisyThe Healthy Lifespan Institute, University of Sheffield, Sheffield, United Kingdom.
Saleh IbrahimDivision of Genetics, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Gaafar RagabRheumatology and Clinical Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Swapan K NathArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European and Asian ancestries, while many other ethnic populations remain underexplored. We conducted the first SLE GWAS on Egyptians-an admixed North African/Middle Eastern population-using 537 patients and 883 controls. To identify novel susceptibility loci and replicate previously known loci, we performed imputation-based association analysis with 6,382,276 SNPs while accounting for individual admixture. We validated the association analysis using adaptive permutation tests (

Indexed as

admixtureEgyptGWASimputationlupus

Identifiers

PMID36324510
PMCPMC9619055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.