Evidence map›Paper›PMID 36324490›Full record

ArticleTherapeutic advances in hematology2022

Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-

Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng and 1 more

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Article in Therapeutic advances in hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Di YaoDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Yuanyuan TianDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Jie LiDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Bohan LiDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Jun LuDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Jing LingDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Defei ZhengDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Yanhua YaoDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Peifang XiaoDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Lijun MengDepartment of Hematology, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou 215025, Jiangsu, China.
Shaoyan HuDepartment of Hematology, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou 215025, Jiangsu, China.ORCID https://orcid.org/0000-0002-5183-2259

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) based on granulocyte colony-stimulating factor plus anti-thymocyte regimens ('Beijing Protocol') provides a salvage treatment for patients of acquired severe aplastic anemia (SAA) in China. However, graft- Objective: The objective of this study was to investigate the impact of UCB co-infusion on GVHD in pediatric patients receiving haplo-HSCT for SAA. Design: We conducted a retrospective study of 91 consecutive SAA children undergoing haploidentical transplantation based on the 'Beijing Protocol' with or without co-infusion of UCB in our center. Methods: All patients received uniform non-myeloablative conditioning and GVHD prophylaxis. We compared baseline characteristics and transplant outcomes between the haplo ( Results: All 91 patients achieved hematopoietic recovery from haploidentical donors, with a higher incidence of peri-engraftment syndrome observed with the haplo-cord group as compared with the haplo group (75.0% Conclusion: Our data indicated that co-infusion of UCB in 'Beijing Protocol'-based haplo-HSCT may be effective for reducing the risk of severe GVHD in SAA children.

Indexed as

acquired severe aplastic anemiachildrengraft-versus-host diseasehaploidentical hematopoietic stem cell transplantationumbilical cord blood

Identifiers

PMID36324490
PMCPMC9619284

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.