ArticleCerebral circulation - cognition and behavior2022
Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey.
Article in Cerebral circulation - cognition and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Vitamin D, systemic inflammation, and motoric cognitive risk: exploring the risk factors and mediation pathways.Frontiers in aging · 2026Article
- A nomogram-based prediction model for motoric cognitive risk syndrome in patients with coronary artery disease: a cross-sectional study.Aging clinical and experimental research · 2025Article
- Association of Motoric Cognitive Risk Syndrome and High C-Reactive Protein Serum Levels With Incident Major Neurocognitive Disorder: Results From the Quebec NuAge Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Observational
- Effect of cognitive behavioral intervention on physical symptoms, B-type natriuretic peptide, red cell distribution width, C-reactive protein in elderly heart failure patients.Journal of cardiothoracic surgery · 2025Article
- Evaluation criteria for diagnosing motoric cognitive risk syndrome: a scoping review.Dementia & neuropsychologia · 2025Review
- Elevated Blood Homocysteine Increases the Risk of Incident Motoric Cognitive Risk Syndrome: A Two-Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Association of 8-hydroxy-2'-deoxyguanosine with motoric cognitive risk in elderly Chinese people: RUGAO longevity and aging cross-sectional study.BMC geriatrics · 2024Article
- Social frailty and the incidence of motoric cognitive risk syndrome in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Biological and Physical Performance Markers for Early Detection of Cognitive Impairment in Older Adults.Journal of clinical medicine · 2024Review
- Editorial.Cerebral circulation - cognition and behavior · 2024Article
- Visual-somatosensory integration (VSI) as a novel marker of Alzheimer's disease: A comprehensive overview of the VSI study.Frontiers in aging neuroscience · 2023Article
- Association of cardiometabolic multimorbidity with motoric cognitive risk syndrome in older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
15 authors at 4 institutions in 5 countries.
Funding
Abstract
Background: Inflammation may play a role in Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome comprised of slow gait and cognitive complaints. Our objective was to examine associations of inflammatory biomarkers with MCR. Methods: We examined association of interleukin-6 (IL-6) and C-reactive protein (CRP) with prevalent MCR using logistic regression in 3,101 older adults (52% female) from five cohorts (National Center for Geriatrics & Gerontology Study of Geriatric Syndromes [NCGG-SGS], Central Control of Mobility in Aging [CCMA], Tasmanian Study of Cognition and Gait [TASCOG], LonGenity, and Einstein Aging Study [EAS]). Associations were reported as odds ratios adjusted for sex, age, education, depressive symptoms, body mass index, and vascular diseases (aOR) with 95% confidence intervals (CI). Meta-analysis and analyses stratified by vascular disease were also done. Results: Although associations between higher (worse) CRP and IL-6 tertiles and MCR were only seen in three out of the five cohorts (EAS, TASCOG, and LonGenity), when a pooled meta-analysis was performed, a robust association was demonstrated. In meta-analysis, highest tertiles of IL-6 (aOR 1.57, 95%CI 1.01- 2.44) and CRP (aOR 1.65, 95%CI 1.09-2.48) was associated with MCR versus lowest tertiles in the pooled sample. Higher CRP was associated with MCR among those with vascular disease in TASCOG and LonGenity cohorts, and among those without vascular disease in EAS. Conclusions: IL-6 and CRP levels are associated with MCR in older adults, and this association varies by presence of vascular disease.
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