Evidence map›Paper›PMID 36324179›Full record

ArticleImmunity & ageing : I & A2022

Ageing-resembling phenotype of long-term allogeneic hematopoietic cells recipients compared to their donors.

Michał Cezary Czarnogórski, Justyna Sakowska, Mateusz Maziewski, Maciej Zieliński, Agnieszka Piekarska, Igor Obuchowski, Mikołaj Młyński, Magdalena Dutka, Alicja Sadowska-Klasa, Ewa Zarzycka and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity & ageing : I & A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Michał Cezary CzarnogórskiDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Justyna SakowskaDepartment of Medical Immunology, Medical University of Gdańsk, Gdańsk, Poland.
Mateusz MaziewskiDepartment of Physiopathology, Medical University of Gdańsk, Gdańsk, Poland.
Maciej ZielińskiDepartment of Medical Immunology, Medical University of Gdańsk, Gdańsk, Poland.
Agnieszka PiekarskaDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Igor ObuchowskiIntercollegiate Faculty of Biotechnology, Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland.
Mikołaj MłyńskiDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Magdalena DutkaDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Alicja Sadowska-KlasaDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Ewa ZarzyckaDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Maria BieniaszewskaDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Piotr TrzonkowskiDepartment of Medical Immunology, Medical University of Gdańsk, Gdańsk, Poland.
Jacek M WitkowskiDepartment of Physiopathology, Medical University of Gdańsk, Gdańsk, Poland.
Andrzej HellmannDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.
Katarzyna Ruckemann-DziurdzińskaDepartment of Pathology and Experimental Rheumatology, Medical University of Gdańsk, Gdańsk, Poland.
Jan M ZauchaDepartment of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland. jzaucha@gumed.edu.pl.
Gdańsk Medical University · PL

Funding

Narodowe Centrum Nauki 2018/31/N/NZ3/01035Narodowe Centrum Nauki 2019/03/X/NZ3/01848
6 · The paper itself

Abstract

backgroundAgeing is a complex phenomenon that leads to decreased proliferative activity, loss of function of the cells, and cellular senescence. Senescence of the immune system exacerbates individual's immune response, both humoral and cellular but increases the frequency of infections. We hypothesized that physiological ageing of adaptive immune system occurs in recipients of allogeneic hematopoietic cells transplant (allo-HCT) at faster rate when compared to their respective donors since the small number of donor cells undergo immense proliferative stress restoring recipients hematopoiesis. We compared molecular characterizations of ageing between recipients and donors of allo-HCT: telomeric length and immunophenotypic changes in main lymphocyte subsets - CD4

resultsMedian telomeric length (TL) of CD8

conclusionOur data do not support the initial hypothesis of accelerated aging in the long term all-HCT recipients with the exception of the recipients lymphocytes (mainly CD8

Indexed as

Ageingallo-HCTImmunosenescenceTelomeric shortening

Identifiers

PMID36324179
PMCPMC9628063
OpenAlexW4308055697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.