Evidence map›Paper›PMID 36324161›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2023

Quantative MRI predicts tendon mechanical behavior, collagen composition, and organization.

Jennifer A Zellers, Masoud Edalati, Jeremy D Eekhoff, Reika McNish, Simon Y Tang, Spencer P Lake, Michael J Mueller, Mary K Hastings, Jie Zheng

Open access · greenAbstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jennifer A ZellersProgram in Physical Therapy, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-0601-1355
Masoud EdalatiMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Jeremy D EekhoffDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
Reika McNishProgram in Physical Therapy, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Simon Y TangDepartment of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-5570-3921
Spencer P LakeDepartment of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Michael J MuellerProgram in Physical Therapy, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Mary K HastingsProgram in Physical Therapy, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Jie ZhengMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Washington University in St. Louis · USMallinckrodt (United States) · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Diabetes-related Tendon Changes: Integrating Ex Vivo and In Vivo ApproachesF32DK123916 · NIDDK · WASHINGTON UNIVERSITY · PI ZELLERS, JENNIFER · 2019 to 2020
$127k
NCATS NIH HHS UL1 TR002345NIDDK NIH HHS F32 DK123916
6 · The paper itself

Abstract

Quantitative magnetic resonance imaging (qMRI) measures have provided insights into the composition, quality, and structure-function of musculoskeletal tissues. Low signal-to-noise ratio has limited application to tendon. Advances in scanning sequences and sample positioning have improved signal from tendon allowing for evaluation of structure and function. The purpose of this study was to elucidate relationships between tendon qMRI metrics (T1, T2, T1ρ and diffusion tensor imaging [DTI] metrics) with tendon tissue mechanics, collagen concentration and organization. Sixteen human Achilles tendon specimens were collected, imaged with qMRI, and subjected to mechanical testing with quantitative polarized light imaging. T2 values were related to tendon mechanics [peak stress (r

Indexed as

Achilles TendonDiffusion Tensor ImagingCollagenDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingCollagenAchillesdiagnostic imagingdiffusion tensor imagingmechanical propertiesmusculoskeletal imaging

Identifiers

PMID36324161
PMCPMC10151441
OpenAlexW4307987673

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.