ArticleCardiovascular diabetology2022
Gender differences in changes in metabolic syndrome status and its components and risk of cardiovascular disease: a longitudinal cohort study.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 58 citations in OpenAlex.
- Article
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- The age- and sex-specific association between metabolic body composition and lung function: a cross-sectional study.Endocrine journal · 2026Observational
- Effect of Statin Use on Mortality in Individuals With Cardiovascular-Kidney-Metabolic Syndrome: A Retrospective Propensity Score-Matched Cohort Study.Cardiovascular therapeutics · 2026Article
- Review
- Longitudinal Associations Between Metabolic Risk Burden and the Cardio-Ankle Vascular Index (CAVI) in Japan Using Health-Check Cohort.Vascular health and risk management · 2026Article
- Article
- Retarded Learning in a Rabbit Model of Metabolic Syndrome Created by Long-Term Feeding of High-Fat Diet and High Sucrose.Nutrients · 2025Article
- Association between neutrophil percentage to albumin ratio and cardiovascular disease in the metabolic syndrome population.Scientific reports · 2025Article
- Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting.BMC oral health · 2025Observational
- Insulin resistance mediates the association between physical activity and mortality in US adults with metabolic syndrome.Scientific reports · 2025Article
- A nationwide comparative analysis of the prevalance and determinants of non-communicable diseases risk factors between Jordanian and displaced Syrian populations.BMC public health · 2025Observational
- Predictive Capacity of Different Indicators of Adiposity for Metabolic Syndrome in Adults in the City of Trujillo, Peru.Medicina (Kaunas, Lithuania) · 2025Article
- Association between the systemic immune-inflammation index and metabolic syndrome and its components: results from the multi-ethnic study of atherosclerosis (MESA).Cardiovascular diabetology · 2025Article
- Sex differences in the prediction of metabolic abnormalities via body mass index in an Eastern Chinese population.Frontiers in nutrition · 2025Article
- Sex Differences in Cardiovascular-Kidney-Metabolic Syndrome: 30-Year US Trends and Mortality Risks-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Early risk detection of metabolic syndrome using sex-specific machine learning models in military personnel.Frontiers in public health · 2025Article
- Optimal Cut-off Points of the Standardized Continuous Metabolic Syndrome Severity Score (cMetS-S) for Predicting Cardiovascular Disease (CVD) and CVD Mortality in the Tehran Lipid and Glucose Study (TLGS).International journal of endocrinology and metabolism · 2024Article
- Association Between Overweight/Obesity Metabolic Phenotypes Defined by Two Criteria of Metabolic Abnormality and Cardiovascular Diseases: A Cross-Sectional Analysis in a Chinese Population.Clinical cardiology · 2024Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
backgroundWe aimed to investigate the gender difference in the association between changes in metabolic syndrome (MetS) and its components with the risk of cardiovascular disease (CVD) and coronary heart disease (CHD) among adult participants in the Tehran lipid and glucose study cohort.
methodsA total of 4624 adults (aged ≥ 30 years) who participated in two Phases 2 (2002-2005) and 3 (2005-2008) were included and followed up until 2018. Based on the status of MetS and its components in two phases, we divided participants into four groups: MetS-free, MetS-developed, MetS-recovery and MetS-stable groups, and similar categories were defined for MetS components. Multiple Cox regression models were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs), and women-to-men ratios of HRs (RHRs).
resultsDuring a median follow-up of 11.6 years, 619 CVD events (292 women) and 512 CHD events (230 women) occurred. In both genders, the MetS-stable group had the highest risk of CVD and CHD, compared with the MetS-free group, but the associations were stronger in women than men: the HR (95% CI) were (2.76, 2.00-3.82) and (3.08, 2.15-4.40) for CVD and CHD, respectively, in women, and (1.60, 1.23-2.09) and (1.74, 1.30-2.31) for men. The multivariate adjusted women-to-men RHRs were (1.72, 1.16-2.56) for CVD and (1.77, 1.14-2.73) for CHD. Only among women, the risks for CVD in MetS-recovery group (1.67, 1.06-2.63) and MetS-developed group (1.89, 1.16-3.06|) were higher than MetS-free group. For CHD, women in MetS-developed group (1.86, 1.07-3.22) had higher risk than MetS-free group. However, no evidence of gender difference was observed in these associations. Among MetS components, persistent high blood pressure (BP) conferred greater risk for CVD and CHD in women than men; the women-to-men RHRs of CVD and CHD for high BP-stable groups were 1.54 (1.05-2.26) and 1.62 (1.07-2.47), respectively. For CHD events, persistent high fasting plasma glucose was associated with greater risk in women than men with women-to-men RHRs of 1.62 (1.09-2.40).
conclusionChange in MetS and its key components were associated with different risks for CVD events in both genders, with generally stronger associations in women than men.
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