ArticleBMC plant biology2022
Evolution of the CBL and CIPK gene families in Medicago: genome-wide characterization, pervasive duplication, and expression pattern under salt and drought stress.
Article in BMC plant biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 17 citations in OpenAlex.
- Biased retention and functional diversification of CESA superfamily genes in Medicago mediating development and abiotic stress responses.BMC plant biology · 2026Article
- In-silico identification, characterization and expression analysis of salt overly sensitive-2 (SOS2) gene family in Gossypium hirsutum L. against abiotic stresses.Scientific reports · 2025Article
- Genome-Wide Identification of the CBL-CIPK Gene Family in the Ice Plant and Functional Analysis of Salt Stress Tolerance.Life (Basel, Switzerland) · 2025Article
- Analysis of WRKY Gene Family inGenes · 2025Article
- Genome-wide analysis of CBL and CIPK gene families in bermudagrass reveals the CdCIPK29-A1 as a stem growth angle regulator.Plant cell reports · 2025Article
- Crop Wild Relatives (CWRs) in the United Arab Emirates: Resources for Climate Resilience and Their Potential Medicinal Applications.Drug design, development and therapy · 2025Review
- Molecular Mechanisms of CBL-CIPK Signaling Pathway in Plant Abiotic Stress Tolerance and Hormone Crosstalk.International journal of molecular sciences · 2024Review
- Crop Wild Relatives: A Valuable Source of Tolerance to Various Abiotic Stresses.Plants (Basel, Switzerland) · 2023Review
- Genome-wide discovery of CBL genes inForestry research · 2023Article
- Genome-wide identification of the CER1 gene family in apple and response of MdCER1-1 to drought stress.Functional & integrative genomics · 2022Article
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Authors and funding
14 authors at 5 institutions in 1 country.
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Abstract
backgroundCalcineurin B-like proteins (CBLs) are ubiquitous Ca
resultsA total of 68 CBL and 135 CIPK genes have been identified in five genomes from Medicago. Among these genomes, the gene number of CBLs and CIPKs shows no significant difference at the haploid genome level. Phylogenetic and comprehensive characteristic analyses reveal that CBLs and CIPKs are classified into four clades respectively, which is validated by distribution of conserved motifs. The synteny analysis indicates that the whole genome duplication events (WGDs) have contributed to the expansion of both families. Expression analysis demonstrates that two MsCBLs and three MsCIPKs are specifically expressed in roots, mature leaves, developing flowers and nitrogen fixing nodules of Medicago sativa spp. sativa, the widely grown tetraploid species. In particular, the expression of these five genes was highly up-regulated in roots when exposed to salt and drought stress, indicating crucial roles in stress responses.
conclusionsOur study leads to a comprehensive understanding of evolution of CBL and CIPK gene families in Medicago, but also provides a rich resource to further address the functions of CBL-CIPK complexes in cultivated species and their closely related wild relatives.
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