ArticleScientific reports2022
Estimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Unveiling the Pre-Weaning Growth Performance and Some Reproductive Characteristics of Akkaraman and Central Anatolian Merino Sheep.Veterinary medicine and science · 2025Article
- Genetic parameter estimation of preweaning growth traits in Akkaraman sheep.Tropical animal health and production · 2024Article
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- Article
- Review of sheep breeding and genetic research in Türkiye.Frontiers in genetics · 2024Review
- Article
- Heritability and environmental influence on pre-weaning traits in Kilis goats.Tropical animal health and production · 2023Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The aim of this study was to estimate genomic heritability and the impact that genetic backgrounds have on blood parameters in Akkaraman sheep by conducting genome-wide association studies and regional heritability mapping analysis. Genomic heritability estimates for blood parameters ranged from 0.00 to 0.55, indicating that measured phenotypes have a low to moderate heritability. A total of 7 genome- and 13 chromosome-wide significant SNPs were associated with phenotypic changes in 15 blood parameters tested. Accordingly, SCN7A, SCN9A, MYADM-like, CCDC67, ITGA9, MGAT5, SLC19A1, AMPH, NTRK2, MSRA, SLC35F3, SIRT6, CREB3L3, and NAV3 genes as well as three undefined regions (LOC101117887, LOC106991526 and LOC105608461) were suggested as candidates. Most of the identified genes were involved in basic biological processes that are essential to immune system function and cellular growth; specific functions include cellular transport, histone deacetylation, cell differentiation, erythropoiesis, and endocytosis. The top significant SNP for HCT, MCH, and MCHC was found within a genomic region mainly populated by the MYADM-like gene family. This region was previously suggested to be under historical selection pressure in many sheep breeds from various parts of the world. These results have implications on animal breeding program studies due to the effect that the genetic background has on blood parameters, which underlying many productive and wellness related traits.
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