ArticleNature2022
Extracellular fluid viscosity enhances cell migration and cancer dissemination.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers.
0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed
42.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
201 citing papers in PubMed, 383 citations in OpenAlex.
- Nuclear mechanobiology in confined cell migration.Nucleus (Austin, Tex.) · 2026Review
- Mechanical regulation of cell memory.Nature structural & molecular biology · 2026Review
- Digestive-transformed titanium dioxide nanoparticles disrupt intestinal barrier via mitoxyperilysis mediated by mTOR-cytoskeleton axis dysregulation.Materials today. Bio · 2026Article
- Phospholipase D2 acts upstream of PI4P 5-kinases in the response of neurons to extracellular viscosity.iScience · 2026Article
- Approaches for recapitulating the extracellular matrix in organs-on-chip.Cell biomaterials · 2026Article
- Mechanical memory as a metastatic compass: a comparative framework for understanding organotropism through biophysical priming.Cancer metastasis reviews · 2026Review
- Transforming destructive mechanical cues into therapeutic power: Activation of PIEZO1 and TRPV4 counteracts mechano-induced damage of cellular junctions in Hailey-Hailey disease.Journal of advanced research · 2026Article
- Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential.Advanced healthcare materials · 2026Review
- Vasculopathy as a mechanical barrier to cancer spread: Clinical evidence and a rheology-based model in lung cancer and other solid tumors.Translational oncology · 2026Article
- Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Microviscosity-gated excited-state partitioning in a NIR-II molecular rotor for disease imaging and imaging-guided photothermal therapy.Materials today. Bio · 2026Article
- Protocol for optogenetic stimulation of cells under physical confinement.STAR protocols · 2026Article
- Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Galvanin: a molecular compass for bioelectric navigation.Cell research · 2026Article
- Compression-induced metabolic adaptation drives confined tumor cell migration and distant metastasis via malate-dependent microtubule reinforcement.Cell research · 2026Article
- Hydrostatic pressure reduces the mechanosensitivity of cell migration.Science advances · 2026Article
- Advancing mechanobiology from single molecules to complex cellular systems.Nature nanotechnology · 2026Review
- IL4I1+ macrophages drive hepatocellular carcinoma progression by responding to biomechanical cues.JHEP reports : innovation in hepatology · 2026Article
- Mechanical regulation of microenvironment remodeling in brain tumors: from mechanism to therapy.Journal of neuroinflammation · 2026Review
141 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 3 countries.
Kaustav BeraDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-0962-4368
Alexander Kiepas *Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8169-3897
Inês Godet *Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Yizeng Li *Department of Biomedical Engineering, Binghamton University, SUNY, Binghamton, NY, USA.
Pranav Mehta *Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Brent IfemembiDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Colin D PaulLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Anindya SenDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Selma A SerraLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Konstantin StoletovDepartment of Oncology, University of Alberta, Edmonton, Alberta, Canada.
Jiaxiang TaoDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD, USA.
Gabriel ShatkinDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Se Jong LeeDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Yuqi ZhangDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Adrianna BoenDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Panagiotis MistriotisDepartment of Chemical Engineering, Auburn University, Auburn, AL, USA.ORCID http://orcid.org/0000-0002-8069-3278
Daniele M GilkesDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3984-9338
John D LewisDepartment of Oncology, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-7734-1204
Chen-Ming FanDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3211-6617
Andrew P FeinbergDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8364-1991
Miguel A ValverdeLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.ORCID http://orcid.org/0000-0002-6961-3361
Sean X SunDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9077-7088
Konstantinos KonstantopoulosDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA. konstant@jhu.edu.ORCID http://orcid.org/0000-0003-2623-1459
Johns Hopkins University · USCarnegie Institution for Science · USUniversitat Pompeu Fabra · ESUniversity of Alberta · CAAuburn University · USBinghamton University · USNational Institutes of Health · US
Funding
MOLECULAR PATHOLOGY OF WILMS TUMOR RELATED GENES 11PR01CA054358 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREW P. FEINBERG · 1991 to 2026
$5.5MViscotaxis: Novel cell migration mechanisms regulated by microenvironmental viscosityR01CA257647 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS · 2021 to 2025
$2.3MThe Role of Hydraulic Pressure in the Osmotic Engine Model of Cell MigrationR01GM134542 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SEAN X SUN · 2019 to 2026
$2.1MIntegrin signaling in skeletal muscle regenerationR01AR071976 · NIAMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI FAN, CHEN-MING · 2017 to 2021
$1.8MProliferation competence of skeletal muscle stem cellsR01AR072644 · NIAMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI FAN, CHEN-MING · 2018 to 2022
$1.8MNCI NIH HHS R01 CA054358NCI NIH HHS R01 CA257647NIAMS NIH HHS R01 AR071976NIAMS NIH HHS R01 AR072644NIGMS NIH HHS R01 GM134542
Abstract
Cells respond to physical stimuli, such as stiffness
Indexed as
Cell MovementExtracellular FluidNeoplasm MetastasisNeoplasmsViscosityActin-Related Protein 2-3 ComplexActinsAnimalsBreast NeoplasmsChick EmbryoEzrinHippo Signaling PathwayLungLung NeoplasmsMicerhoA GTP-Binding ProteinActin-Related Protein 2-3 ComplexActinsEzrinrhoA GTP-Binding ProteinSodium-Hydrogen ExchangersTRPV Cation Channels
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.