ArticleNature2022
Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 112 citations in OpenAlex.
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Integrating delivery systems and microenvironmental cues to accelerate clinical translation of cardiac reprogramming.Materials today. Bio · 2026Review
- The gut neuroepithelial unit as a neurodegeneration-relevant interface in the gut-brain axis.Translational neurodegeneration · 2026Review
- IL-9 Is Essential for ILC2-Mediated but Not Th2- and Th17-Cell-Mediated Allergic Airway Inflammation in Mice.European journal of immunology · 2026Article
- Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation.Immunity · 2026Article
- ILC2s regulate a fibroblast progenitor niche in the pancreas.Science (New York, N.Y.) · 2026Article
- Androgens protect ILC2S from functional suppression during influenza virus infection.Mucosal immunology · 2026Article
- Innate lymphoid cells in rheumatoid arthritis as mediators of pathology and resolution.Nature reviews. Rheumatology · 2026Review
- IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma.Nature immunology · 2026Article
- The Epidermal Growth Factor Receptor (EGFR) as a means of neuro-immune cross-conversation.Journal of neuroinflammation · 2026Review
- Nmur1 and Cckar fail to support functional genetic access in adult dopamine neurons and challenge GPCR atlas assignments.bioRxiv : the preprint server for biology · 2026Article
- Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity.The Journal of experimental medicine · 2026Article
- Review
- Ferroptosis shapes ILC2 responses in inflammatory bowel disease.Cellular & molecular immunology · 2026Article
- ILC2s and their immune checkpoints in the antitumor response.Journal for immunotherapy of cancer · 2026Review
- GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression.Cellular & molecular immunology · 2026Article
- Disturbed LTB4 Metabolism in ILC2s Aggravates Ulcerative Colitis via Intercellular ATP Accumulation.Inflammation · 2026Article
- Article
- Human type-1 innate lymphoid cells control leukemia stem cell differentiation and limit acute myeloid leukemia development.Nature communications · 2026Article
- Distinguishing Features of ILC2s During Type 2 Immune Responses.European journal of immunology · 2026Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
18 authors at 4 institutions in 2 countries.
Amy M Tsou *Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Hiroshi Yano *Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-3098-2629
Christopher N ParkhurstJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Tanel MahlakõivJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Coco ChuJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Wen ZhangJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Zhengxiang HePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8961-859X
Katja J JarickCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Microbiology, Infectious Diseases and Immunology, Berlin, Germany.ORCID http://orcid.org/0000-0001-5162-7266
Connie ZhongJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Gregory G PutzelJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Mai HatazakiJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
JRI IBD Live Cell Bank Consortium
Ivo C LorenzTri-Institutional Therapeutics Discovery Institute, New York, NY, USA.
David AndrewTri-Institutional Therapeutics Discovery Institute, New York, NY, USA.
Paul BalderesTri-Institutional Therapeutics Discovery Institute, New York, NY, USA.
Christoph S N KloseCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Microbiology, Infectious Diseases and Immunology, Berlin, Germany.ORCID http://orcid.org/0000-0001-8803-2979
Sergio A LiraPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6742-3089
David ArtisJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA. dartis@med.cornell.edu.ORCID http://orcid.org/0000-0002-1753-4100
Cornell University · USTri-Institutional Therapeutics Discovery Institute · USHumboldt-Universität zu Berlin · DEIcahn School of Medicine at Mount Sinai · US
Funding
Regulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0MMultidisciplinary Approach Training in Respiratory ResearchT32HL134629 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Robert J Kaner, Heather Winona Stout Delgado · 2018 to 2026
$5.2MMechanisms associated with flares and remission in colitisR01DK110352 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2017 to 2025
$5.1MMicrobiota-derived metabolites and the regulation of host immunity and inflammation (Diversity Supplement)R01AI172027 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI David Artis, Chun-Jun Guo · 2022 to 2026
$4.4MNeuroimmune Regulation of Atopic DermatitisR01AR070116 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2016 to 2021
$3.8MRegulation and function of innate lymphoid cells in the gutR01AI095466 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2011 to 2022
$3.7MNeuropeptide-mediated regulation of antihelminth immunityR01AI151599 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ARTIS, DAVID, SIRACUSA, MARK CHRISTOPHER · 2020 to 2024
$3.2MNeuro-immune regulation of intestinal inflammationR01DK126871 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2020 to 2024
$3.2MDietary Regulation of Intestinal Inflammation and RepairR01DK132244 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, GUO, CHUN-JUN · 2022 to 2025
$2.7MMechanisms associated with diet-induced colitisR01DK121009 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2020 to 2023
$2.4MMicrobial Regulation of Microglial FunctionK08MH130773 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PARKHURST, CHRISTOPHER NEAL · 2022 to 2025
$782kMicrobiota-dependent regulation of the gut-brain axisR21AI142213 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2019 to 2020
$466kEuropean Research Council 803087NHLBI NIH HHS T32 HL134629NIAID NIH HHS R01 AI095466NIAID NIH HHS R01 AI151599NIAID NIH HHS R01 AI172027NIAID NIH HHS R21 AI142213NIAID NIH HHS U01 AI095608NIAMS NIH HHS R01 AR070116NIDDK NIH HHS R01 DK110352NIDDK NIH HHS R01 DK121009NIDDK NIH HHS R01 DK126871NIDDK NIH HHS R01 DK132244NIMH NIH HHS K08 MH130773
Abstract
Emerging studies indicate that cooperation between neurons and immune cells regulates antimicrobial immunity, inflammation and tissue homeostasis. For example, a neuronal rheostat provides excitatory or inhibitory signals that control the functions of tissue-resident group 2 innate lymphoid cells (ILC2s) at mucosal barrier surfaces
Indexed as
Immunity, InnateIntestinal MucosaLymphocytesNeuropeptidesAmphiregulinAnimalsCytokinesHumansInflammationIntegrasesMiceReceptors, G-Protein-CoupledReceptors, NeuropeptideReceptors, NeurotransmitterAmphiregulinCre recombinaseCytokinesIntegrasesneuromedin UNeuropeptidesNMUR1 protein, humanNmur1 protein, mouseReceptors, G-Protein-CoupledReceptors, NeuropeptideReceptors, Neurotransmitter
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.