ArticleNature2022
Nociceptor neurons affect cancer immunosurveillance.
Open access · hybridAbstract read
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers.
0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed
36.1field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
202 citing papers in PubMed, 279 citations in OpenAlex.
- Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma.Oncoimmunology · 2026Article
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Mechanisms of neuropeptide-mediated immune sensing in the modulation of antitumor immunity.Journal for immunotherapy of cancer · 2026Review
- Neural-tumor interactions: bidirectional regulatory mechanisms and nervous system-targeted tumor therapeutic strategies.Biomarker research · 2026Review
- Targeting of tripartite neuron-cancer-immune cell crosstalk augments response to chemotherapy and immunotherapy.Cell reports. Medicine · 2026Article
- Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- Integration of Multi-Omics Data To Understand the Multifaceted Role of RAMP1 across Different Cancer Types.Cell biochemistry and biophysics · 2026Review
- Cancer-related pain: A bidirectional modulator of cancer progression.Clinical and translational medicine · 2026Review
- Neuron-Associated Transcriptional Enrichment Is Associated with Distinct Biological States and Predicts Poor Prognosis in Gastric Cancer.Annals of surgical oncology · 2026Article
- Cancer Neuroscience: From Local Neuro-Immune Microenvironments to Systemic Brain-Body Circuitry.MedComm · 2026Review
- Decoding age-stratified clinical and molecular heterogeneity in male breast cancer through multiomic profiling.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Nociceptor neurons suppress antitumor immunity in breast cancer.Research square · 2026Article
- Spatially organized regulated cell death-immune coupling in solid tumors: integrating spatial omics with actionable regulated cell death biology.Molecular cancer · 2026Review
- Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Association of tumor Schwann cells with epithelial-mesenchymal transition and immune-suppressive microenvironment in triple-negative breast cancer.Breast cancer research and treatment · 2026Article
- Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy.Experimental & molecular medicine · 2026Review
- Review
- Cancer-induced nerve injury unveils a sympathetic-to-sensory nerve axis in a mouse model of head and neck squamous cell carcinoma.Science translational medicine · 2026Article
- Metastatic Cancers Exploit Vagal Sensory Neurons and Neural Repair Programs to Colonize New Tissues.Research square · 2026Article
- A Neuron Projection Guidance Signature Associates with Immune-Cold Tumor Microenvironment and Poor Outcomes in Breast Cancer.Annals of surgical oncology · 2026Article
142 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 10 institutions in 3 countries.
Mohammad Balood *Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Maryam Ahmadi *Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Tuany EichwaldDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Ali AhmadiDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Abdelilah MajdoubiDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Quebec, Canada.
Karine RoversiDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Katiane RoversiDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Christopher T LucidoCancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.
Anthony C RestainoCancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.ORCID http://orcid.org/0000-0002-5562-2670
Siyi HuangCygnal Therapeutics, Cambridge, MA, USA.
Lexiang JiCygnal Therapeutics, Cambridge, MA, USA.
Kai-Chih HuangCygnal Therapeutics, Cambridge, MA, USA.
Elise SemerenaDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0002-8954-6274
Sini C ThomasDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Alexandro E TrevinoF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Hannah MerrisonF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Alexandre ParrinF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Benjamin DoyleF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Daniel W VermeerCancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.
William C SpanosCancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.ORCID http://orcid.org/0000-0002-7975-1151
Caitlin S WilliamsonCancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.
Corey R SeehusF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Simmie L FosterDepression Clinical Research Program, Massachusetts General Hospital, Boston, MA, USA.
Hongyue DaiCygnal Therapeutics, Cambridge, MA, USA.
Chengyi J ShuCygnal Therapeutics, Cambridge, MA, USA.
Manu RangachariDépartement de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec, Quebec, Canada.
Jacques ThibodeauDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Quebec, Canada.
Sonia V Del RinconDepartment of Oncology, McGill University, Montréal, Quebec, Canada.
Ronny DrapkinPenn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6912-6977
Moutih RafeiDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Nader GhasemlouDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID http://orcid.org/0000-0002-1696-7342
Paola D VermeerCancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.ORCID http://orcid.org/0000-0003-2370-8223
Clifford J WoolfF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6636-3897
Sebastien TalbotDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada. sebastien.talbot@queensu.ca.
Université de Montréal · CABoston Children's Hospital · USSanford Research · USCygnal Therapeutics (United States) · USQueen's University · CAUniversité Laval · CACancer Research Center · USMassachusetts General Hospital · USMcGill University · CAUniversidade Federal de Santa Catarina · BR
Funding
Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2MThe Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8MTracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3MUnravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MNICHD NIH HHS P50 HD105351NIGMS NIH HHS P20 GM103548NIGMS NIH HHS P20 GM103620NIGMS NIH HHS U54 GM128729NINDS NIH HHS R35 NS105076
Abstract
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems
Indexed as
CD8-Positive T-LymphocytesMelanomaNociceptorsAnimalsBiopsyCalcitonin Gene-Related PeptideGenes, RAG-1HumansLymphocytes, Tumor-InfiltratingMelanoma, ExperimentalMiceNeuritesPrognosisReceptor Activity-Modifying Protein 1Sensory Receptor CellsSurvival RateCalcitonin Gene-Related PeptideRAMP1 protein, humanRamp1 protein, mouseReceptor Activity-Modifying Protein 1TRPV1 protein, mouseTRPV Cation Channels
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.