Evidence map›Paper›PMID 36323692›Full record

ArticleNPJ microgravity2022

Endothelial dysfunction markers and immune response indices in cosmonauts' blood after long-duration space flights.

D S Kuzichkin, I A Nichiporuk, O A Zhuravleva, A A Markin, M P Rykova, T V Zhuravleva, A A Sadova, O V Kutko, V A Shmarov, S A Ponomarev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. [Potential biological mechanisms underlying spaceflight-induced depression symptoms in astronauts].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

D S KuzichkinState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia. dmitry161985@mail.ru.ORCID http://orcid.org/0000-0003-2252-6380
I A NichiporukState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0003-0118-3374
O A ZhuravlevaState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0002-3049-4983
A A MarkinState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.
M P RykovaState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0002-9121-5351
T V ZhuravlevaState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0002-1179-1309
A A SadovaState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0002-7633-9460
O V KutkoState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0002-5522-7777
V A ShmarovState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0001-7156-3415
S A PonomarevState Scientific Center of the Russian Federation - Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0002-5364-7815
Institute of Biomedical Problems · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Space flight factors are known to cause a malfunction in the human immune system and lead to damage to blood vessels. The hemostatic function of endothelium during space missions and its interaction with human immunity has not been determined so far. In this work, we investigated the markers of endothelial activation and damage (plasma concentrations of soluble thrombomodulin fraction (sTM), von Willebrand factor (vWF), highly sensitive C-reactive protein (hs-CRP)), as well as the level of D-dimer and compared them to the immunological parameters characterizing the state of human humoral and cellular immunity. The immune status of long-duration ISS crewmembers was assessed by whole-blood testing, and comprehensive postflight immune assessment included the analysis of leukocyte distribution. Flow cytometry was applied to determine the absolute counts and the percentage of lymphocyte subsets: B cells (CD19

Identifiers

PMID36323692
PMCPMC9630277
OpenAlexW4308057526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.