ReviewBritish journal of sports medicine2023
Exploring the role of intratendinous pressure in the pathogenesis of tendon pathology: a narrative review and conceptual framework.
Review in British journal of sports medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Effectiveness of reducing tendon compression in the rehabilitation of insertional Achilles tendinopathy: a randomised clinical trial.British journal of sports medicine · 2025Trial
- A modular self-assembling peptide platform targeting TGF-β1 for tendon regeneration.Nature communications · 2026Article
- Therapeutic Effect of Photobiomodulation and Single Intratendinous Injection at the Lesion Site of Platelet-Rich Fibrin in Inducted Tendinopathy.Journal of biophotonics · 2026Article
- Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Superior oblique split tendon lengthening for management of brown syndrome.International ophthalmology · 2025Article
- Pathological Classification of Lateral Elbow Tendinopathy Based on Fiber Orientation, Blood Flow Velocity of Radial Recurrent Artery, and Patient-Reported Outcome Measures.Journal of clinical medicine · 2025Article
- Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The Safety of Ultrasound-Guided Needle Approaches for Patellar Tendinopathy: A Theoretical Cadaveric Model.Journal of functional morphology and kinesiology · 2025Article
- Novel Insights Into the Intratendinous Pressure Behavior of the Achilles Tendon in Athletes.Sports health · 2025Observational
- Narrative review of long-standing groin pain in athletes. Retrospective analysis of over 12 000 patients.Hernia : the journal of hernias and abdominal wall surgery · 2025Review
- Elevated fluid and glycosaminoglycan content in the Achilles tendon contribute to higher intratendinous pressures: Implications for Achilles tendinopathy.Journal of sport and health science · 2024Article
- Posterior Tibial Artery Blood Flow Velocity Is Increased in Patients with Plantar Heel Pain.Journal of clinical medicine · 2024Article
- Article
- Animal model for tendinopathy.Journal of orthopaedic translation · 2023Review
- Ultrasonography for Injecting (Around) the Lateral Epicondyle: EURO-MUSCULUS/USPRM Perspective.Diagnostics (Basel, Switzerland) · 2023Review
- A Rare Septuagenarian Patient with a Mild Form of Mucopolysaccharidosis Type IIIC with Ocular Manifestations: A Case Report.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the high prevalence of tendon pathology in athletes, the underlying pathogenesis is still poorly understood. Various aetiological theories have been presented and rejected in the past, but the tendon cell response model still holds true. This model describes how the tendon cell is the key regulator of the extracellular matrix and how pathology is induced by a failed adaptation to a disturbance of tissue homeostasis. Such failure has been attributed to various kinds of stressors (eg, mechanical, thermal and ischaemic), but crucial elements seem to be missing to fully understand the pathogenesis. Importantly, a disturbance of tissue pressure homeostasis has not yet been considered a possible factor, despite it being associated with numerous pathologies. Therefore, we conducted an extensive narrative literature review on the possible role of intratendinous pressure in the pathogenesis of tendon pathology. This review explores the current understanding of pressure dynamics and the role of tissue pressure in the pathogenesis of other disorders with structural similarities to tendons. By bridging these insights with known structural changes that occur in tendon pathology, a conceptual model was constituted. This model provides an overview of the possible mechanism of how an increase in intratendinous pressure might be involved in the development and progression of tendon pathology and contribute to tendon pain. In addition, some therapies that could reduce intratendinous pressure and accelerate tendon healing are proposed. Further experimental research is encouraged to investigate our hypotheses and to initiate debate on the relevance of intratendinous pressure in tendon pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.