Evidence map›Paper›PMID 36323465›Full record

ArticleBMJ open2022

Industry strategies to market opioids to children and women in the USA: a content analysis of internal industry documents from 1999 to 2017 released in State of Oklahoma v. Purdue Pharma, L.P.

Hanna Yakubi, Brian Gac, Dorie E Apollonio

Abstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Article
  4. Healthcare (Basel, Switzerland) · 2025
    Article
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  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hanna YakubiDepartment of Clinical Pharmacy, University of California, San Francisco, California, USA.
Brian GacDepartment of Clinical Pharmacy, University of California, San Francisco, California, USA.
Dorie E ApollonioDepartment of Clinical Pharmacy, University of California, San Francisco, California, USA dorie.apollonio@ucsf.edu.ORCID 0000-0003-4694-0826

Funding

Linking local variation in marijuana and opioid policies to health outcomesR21DA046051 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI APOLLONIO, DOROTHY ELINOR, RAMO, DANIELLE E · 2019 to 2020
$442k
NIDA NIH HHS R21 DA046051
6 · The paper itself

Abstract

objectiveIdentify advertising strategies used to market opioids to women and children.

designQualitative content analysis of internal pharmaceutical industry documents released in litigation, dated between 1999 and 2017.

settingUSA.

participantsOpioid manufacturers (Janssen, Ortho-McNeil, Purdue, Teva (Actavis), Janus, Cephalon); women; children. PRIMARY AND SECONDARY OUTCOME MEASURES: Advertising campaigns, industry executive statements regarding marketing goals

methodsWe examined ((DATASET) link: https://www.industrydocuments.ucsf.edu/drug/) documents released in State of Oklahoma v. Johnson & Johnson (2019) to identify marketing strategies and campaigns developed by opioid manufacturers that focused on children and women, as well as public records, including websites developed by manufacturers and their allies, to confirm whether marketing campaigns proposed in internal industry documents were implemented. Documents identified as relevant were coded for themes based on expectations drawn from previous research on marketing using internal industry documents, which included making emotional appeals and understating the risks of addiction.

resultsWe found that opioid manufacturers sought to recruit coaches and school nurses to encourage opioid use by children, developed unbranded initiatives suggesting adolescents ask providers for pain care medications, suggested that opioid use could reduce health risks associated with untreated pain among women and advocated to policy makers that women faced unmet needs for pain medication.

conclusionsThe USA strictly regulates direct marketing of medications but does not place the same restrictions on indirect marketing and unbranded campaigns, which encourage people to seek treatment without indicating the names of specific products. Opioid manufacturers in the early 21st century appear to have relied largely on unbranded campaigns for marketing, which they described externally as public health promotion and internally as a way to increase sales of opioids. The rapid increase in opioid use concomitant with these campaigns suggests that additional scrutiny of this kind of marketing may be needed in order to protect vulnerable groups.

Indexed as

Analgesics, OpioidTobacco IndustryAdolescentAdvertisingChildFemaleHumansMarketingOklahomaPainAnalgesics, Opioidhealth policypaediatricspain managementpublic healthqualitative research

Identifiers

PMID36323465
PMCPMC9639061

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.