Evidence map›Paper›PMID 36323322›Full record

ArticleNeuron2023

Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold.

Gioele W Albisetti, Robert P Ganley, Francesca Pietrafesa, Karolina Werynska, Marília Magalhaes de Sousa, Rebecca Sipione, Louis Scheurer, Michael R Bösl, Pawel Pelczar, Hendrik Wildner and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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  7. CaInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Gioele W AlbisettiInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland.
Robert P GanleyInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland.
Francesca PietrafesaInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland.
Karolina WerynskaInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland.
Marília Magalhaes de SousaInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland.
Rebecca SipioneInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland.
Louis ScheurerInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland.
Michael R BöslInstitute of Experimental Biomedicine I, University Hospital Würzburg, and Rudolf Virchow Center, University of Würzburg, 97080 Würzburg, Germany.
Pawel PelczarCenter for Transgenic Models, University of Basel, 4001 Basel, Switzerland.
Hendrik WildnerInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland. Electronic address: hwildner@pharma.uzh.ch.
Hanns Ulrich ZeilhoferInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zürich, 8093 Zürich, Switzerland; Center for Neuroscience Zurich (ZNZ), 8057 Zürich, Switzerland; Drug Discovery Network Zurich (DDNZ), 8057 Zürich, Switzerland. Electronic address: zeilhofer@pharma.uzh.ch.
University of Zurich · CHUniversity of Basel · CHUniversity of Würzburg · DE

Funding

Wellcome Trust
6 · The paper itself

Abstract

Proper sensing of ambient temperature is of utmost importance for the survival of euthermic animals, including humans. While considerable progress has been made in our understanding of temperature sensors and transduction mechanisms, the higher-order neural circuits processing such information are still only incompletely understood. Using intersectional genetics in combination with circuit tracing and functional neuron manipulation, we identified Kcnip2-expressing inhibitory (Kcnip2

Indexed as

Cold TemperatureSpinal Cord Dorsal HornAnimalsHumansInterneuronsKv Channel-Interacting ProteinsMiceNeuronsPosterior Horn CellsKcnip2 protein, mouseKv Channel-Interacting Proteinscircuitcoldcold allodyniacold analgesiacoolingdre recombinaseinterneuronintersectional gene targetingkcnip2pain

Identifiers

PMID36323322
PMCPMC9831669
OpenAlexW4308030382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.