ArticleImmunity2022
Meningeal macrophages protect against viral neuroinfection.
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Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
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Who cites it
67 citing papers in PubMed, 86 citations in OpenAlex.
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
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- Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies.Translational neurodegeneration · 2026Review
- Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor.Cell reports · 2026Article
- IL-4 in Alzheimer's Disease-Mechanisms and Therapeutic Potential.Molecular neurobiology · 2026Review
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- Integrative proteomics and lipidomics reveals dual roles for lipid droplets in the host cell antiviral response.Nature communications · 2026Article
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- Breaking barriers: how cytomegaloviruses manipulate myeloid cells to invade tissues.EMBO reports · 2026Review
- Engulfment by brain macrophages in a short-lived vertebrate.bioRxiv : the preprint server for biology · 2026Article
- Hexokinase 3 promoted cytokine production of monocytes by targeting metabolic reprogramming and histone lactylation in sepsis.Clinical epigenetics · 2026Article
- Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins.Nature neuroscience · 2026Article
- The cribriform plate: A dynamic central nervous system-immune hub.The Journal of experimental medicine · 2026Review
- Reprogramming brain-resident macrophages: from disease drivers to therapeutic allies in neurological disorders.Frontiers in cellular neuroscience · 2026Review
- Stromal Cell-Mast Cell Communication Orchestrates Anti-Viral Immunity in the Meninges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gut irradiation and microbiota status modulate the meningeal immune landscape.Discovery immunology · 2026Article
- Integrating brain organoids, meningeal immunity, and glymphatic dynamics: toward modeling neuroimmune clearance and crosstalk in disease.Frontiers in immunology · 2026Review
- IL-34 in neurological homeostasis and its multifaceted roles in central nervous system diseases.Frontiers in immunology · 2026Review
- Conserved phenotype and function of human brain border-associated macrophages in iPSC-derived models.bioRxiv : the preprint server for biology · 2025Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 5 institutions in 4 countries.
Julie RebejacCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Elisa Eme-ScolanCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France; École Normale Supérieure de Lyon, Université Claude Bernard - Lyon I, Université de Lyon, Lyon, France.
Laurie Arnaud ParoutaudCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Sarah KharboucheCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Matei TelemanCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Lionel SpinelliCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Emeline GalloCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Annie Roussel-QuevalCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Ana ZarubicaCentre d'Immunophénomique, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Amandine SansoniCentre d'Immunophénomique, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Quentin BardinCentre d'Immunophénomique, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Philippe HoestCentre d'Immunophénomique, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Marie-Cécile MichalletTERI (Tumor Escape, Resistance and Immunity) Department, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Université Claude Bernard - Lyon 1, Université de Lyon, Inserm, CNRS, Lyon, France.
Carine BrousseCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Karine CrozatCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Monica ManglaniViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Zhaoyuan LiuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Florent GinhouxShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; University Paris-Saclay, Inserm U1015, Gustave Roussy Cancer Center, Villejuif, France; Singapore Immunology Network, A(∗)STAR, Singapore, Singapore.
Dorian B McGavernViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Marc DalodCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Bernard MalissenCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France; Centre d'Immunophénomique, Aix Marseille Université, Inserm, CNRS, Marseille, France.
Toby LawrenceCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France; Centre for Inflammation Biology and Cancer Immunology, Cancer Research UK King's Health Partners Centre, School of Immunology and Microbial Sciences, King's College London, London SE1 1UL, UK.
Rejane RuaCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Marseille, France. Electronic address: rua@ciml.univ-mrs.fr.
Centre National de la Recherche Scientifique · FRNational Institutes of Health · USUniversité Claude Bernard Lyon 1 · FRInserm · FRShanghai Jiao Tong University · CN
Funding
Pathogenesis of viral meningitisZIANS003112 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.6MIntramural NIH HHS ZIA NS003112
Abstract
The surface of the central nervous system (CNS) is protected by the meninges, which contain a dense network of meningeal macrophages (MMs). Here, we examined the role of tissue-resident MM in viral infection. MHC-II
Indexed as
COVID-19Lymphocytic ChoriomeningitisAnimalsLipopolysaccharidesLymphocytic choriomeningitis virusMacrophagesMeningesMiceMice, Inbred C57BLSARS-CoV-2Lipopolysaccharidesbrainimmunological barrierinterferonLCMVmacrophagesmeningesneuroinfectionvirus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.