Evidence map›Paper›PMID 36322923›Full record

ArticleACS nano2022

Microneedle Patches Loaded with Nanovesicles for Glucose Transporter-Mediated Insulin Delivery.

Qian Chen, Zhisheng Xiao, Chao Wang, Guojun Chen, Yuqi Zhang, Xudong Zhang, Xiao Han, Jinqiang Wang, Xiao Ye, Mark R Prausnitz and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 83 citations in OpenAlex.

  1. Programmable Self-Heating Microneedle Patch for on-Demand Postprandial Glucose Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  13. Microneedle delivery platform integrated withActa pharmaceutica Sinica. B · 2025
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  18. Microfluidic-based systems for the management of diabetes.Drug delivery and translational research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Qian ChenDepartment of Bioengineering, University of California, Los Angeles, California 90095, United States.ORCID 0000-0002-1487-5479
Zhisheng XiaoInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
Chao WangJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0002-8054-3472
Guojun ChenDepartment of Bioengineering, University of California, Los Angeles, California 90095, United States.ORCID 0000-0002-3272-2943
Yuqi ZhangDepartment of Bioengineering, University of California, Los Angeles, California 90095, United States.
Xudong ZhangDepartment of Bioengineering, University of California, Los Angeles, California 90095, United States.
Xiao HanDepartment of Bioengineering, University of California, Los Angeles, California 90095, United States.
Jinqiang WangDepartment of Bioengineering, University of California, Los Angeles, California 90095, United States.
Xiao YeGeriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.
Mark R PrausnitzSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Song LiDepartment of Bioengineering, University of California, Los Angeles, California 90095, United States.ORCID 0000-0002-4760-8828
Zhen GuDepartment of Bioengineering, University of California, Los Angeles, California 90095, United States.ORCID 0000-0003-2947-4456
University of North Carolina at Chapel Hill · USCalifornia NanoSystems Institute · USBlood Center of Zhejiang Province · CNGeorgia Institute of Technology · USSoochow University · CN

Funding

Towards Glucose Transporter-Mediated Glucose-Responsive Insulin Delivery with Fast ResponseR01DK112939 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2018 to 2022
$2.2M
Platelets-Mediated Delivery of Checkpoint Inhibitors for Post-Surgical Cancer ImmunotherapyR01CA234343 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2023
$2.0M
NCI NIH HHS R01 CA234343NIDDK NIH HHS R01 DK112939
6 · The paper itself

Abstract

Glucose-responsive insulin delivery systems that mimic insulin secretion activity in the pancreas show great potential to improve clinical therapeutic outcomes for people with type 1 and advanced type 2 diabetes. Here, we report a glucose-responsive insulin delivery microneedle (MN) array patch that is loaded with red blood cell (RBC) vesicles or liposome nanoparticles containing glucose transporters (GLUTs) bound with glucosamine-modified insulin (Glu-Insulin). In hyperglycemic conditions, high concentrations of glucose in interstitial fluid can replace Glu-Insulin

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2AnimalsBlood GlucoseDrug Delivery SystemsGlucoseGlucose Transport Proteins, FacilitativeInsulinLiposomesMiceNeedlesBlood GlucoseGlucoseGlucose Transport Proteins, FacilitativeInsulinLiposomesdiabetesdrug deliveryglucose-responsiveglucose transportermicroneedles

Identifiers

PMID36322923
PMCPMC10738036
OpenAlexW4308053633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.