Evidence map›Paper›PMID 36322873›Full record

ArticleBlood advances2023

Patient-reported outcomes in children with sickle cell disease at presentation for an acute pain episode.

Nitya Bakshi, Zihao Liu, Scott Gillespie, Rohali Keesari, Deborah Leake, Kirshma Khemani, Polly Kumari, Chris A Rees, Carlton Dampier, Claudia R Morris

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02536170 (Phase 2 Randomized Control Trial of Arginine Therapy for Pediatric Sickle Cell Disease Pain), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02536170 phase2completednot on this map

Phase 2 Randomized Control Trial of Arginine Therapy for Pediatric Sickle Cell Disease Pain

TypeinterventionalSponsorEmory UniversityRan2016 to 2021Enrolled108ConditionsSickle Cell Disease, Vaso-occlusive Pain EpisodeArmsL-arginine, L-arginine Loading Dose, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nitya BakshiDivision of Pediatric Hematology-Oncology-Blood and Marrow Transplant, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-0876-9506
Zihao LiuRollins School of Public Health, Emory University, Atlanta, GA.
Scott GillespiePediatric Biostatistics Core, Emory University, Atlanta, GA.
Rohali KeesariPediatric Biostatistics Core, Emory University, Atlanta, GA.
Deborah LeakeChildren's Healthcare of Atlanta, Atlanta, GA.
Kirshma KhemaniDivision of Pediatric Hematology-Oncology-Blood and Marrow Transplant, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Polly KumariDivision of Pediatric Emergency Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Chris A ReesChildren's Healthcare of Atlanta, Atlanta, GA.ORCID 0000-0001-6449-0377
Carlton DampierDivision of Pediatric Hematology-Oncology-Blood and Marrow Transplant, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-7738-2620
Claudia R MorrisChildren's Healthcare of Atlanta, Atlanta, GA.ORCID 0000-0001-6019-2858

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Phase 2 RCT of Arginine Therapy for Pediatric SCD Pain IND #66,943 1/18/13 ActiveR01FD004814 · FDA · EMORY UNIVERSITY · PI MORRIS, CLAUDIA R · 2015 to 2018
$1.6M
Patient-Oriented Research in Arginine Deficiency SyndromesK24AT009893 · NCCIH · EMORY UNIVERSITY · PI Claudia R Morris · 2018 to 2026
$1.5M
STUDYING INTRA-INDIVIDUAL PAIN VARIABILITY IN SICKLE CELL DISEASE AND RESOLUTION OF PAIN AFTER HEMATOPOIETIC CELL TRANSPLANT: A NOVEL MODEL SYSTEM TO ELUCIDATE MECHANISMS OF TRANSITION TO CHRONIC PAINK23HL140142 · NHLBI · YALE UNIVERSITY · PI BAKSHI, NITYA · 2018 to 2022
$899k
FDA HHS R01 FD004814NCATS NIH HHS UL1 TR002378NCCIH NIH HHS K24 AT009893NHLBI NIH HHS K23 HL140142
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute PainAnemia, Sickle CellChildHumansPatient Reported Outcome Measures

Identifiers

PMID36322873
PMCPMC10477437

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.