ArticleProceedings of the National Academy of Sciences of the United States of America2022
Spontaneous phase coordination and fluid pumping in model ciliary carpets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Physical Frameworks and Theories on How Autonomous Biological Oscillators Synchronize.Advances in experimental medicine and biology · 2026Review
- Modeling tissue-scale ciliary transport and mixing in three-dimensional Newtonian flow.PLoS computational biology · 2025Article
- Dynamics and emergence of metachronal waves in the ciliary band of a metazoan larva.Science advances · 2025Article
- Cilia dynamics create a dynamic barrier to penetration of the periciliary layer in human airway epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structure and function relationships of mucociliary clearance in human and rat airways.Nature communications · 2025Article
- Structure and Function Relationships of Mucociliary Clearance in Human and Rat Airways.bioRxiv : the preprint server for biology · 2025Article
- Active fluctuations of axoneme oscillations scale with number of dynein motors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Flow Physics Guides Morphology of Ciliated Organs.Nature physics · 2024Article
- Near-field hydrodynamic interactions determine travelling wave directions of collectively beating cilia.Journal of the Royal Society, Interface · 2024Article
- STRUCTURE-FUNCTION RELATIONSHIPS OF MUCOCILIARY CLEARANCE IN HUMAN AIRWAYS.Research square · 2024Article
- Epithelial NaComprehensive Physiology · 2024Review
- Nonreciprocal interactions give rise to fast cilium synchronization in finite systems.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Ciliated tissues, such as in the mammalian lungs, brains, and reproductive tracts, are specialized to pump fluid. They generate flows by the collective activity of hundreds of thousands of individual cilia that beat in a striking metachronal wave pattern. Despite progress in analyzing cilia coordination, a general theory that links coordination and fluid pumping in the limit of large arrays of cilia remains lacking. Here, we conduct in silico experiments with thousands of hydrodynamically interacting cilia, and we develop a continuum theory in the limit of infinitely many independently beating cilia by combining tools from active matter and classical Stokes flow. We find, in both simulations and theory, that isotropic and synchronized ciliary states are unstable. Traveling waves emerge regardless of initial conditions, but the characteristics of the wave and net flows depend on cilia and tissue properties. That is, metachronal phase coordination is a stable global attractor in large ciliary carpets, even under finite perturbations to cilia and tissue properties. These results support the notion that functional specificity of ciliated tissues is interlaced with the tissue architecture and cilia beat kinematics and open up the prospect of establishing structure to function maps from cilium-level beat to tissue-level coordination and fluid pumping.
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