Evidence map›Paper›PMID 36322748›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes.

John D Hong, David Salom, Michał Andrzej Kochman, Adam Kubas, Philip D Kiser, Krzysztof Palczewski

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Structural analysis of rhodopsin states in megabody complexes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Structure of human green cone opsin yields insights into mechanisms underlying the rapid decay of its active, signaling state.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Significance of Vitamins A and E in Cancer Progression and Prevention.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Review
  9. Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. The First Steps of the Visual Cycle in Human Rod and Cone Photoreceptors.Investigative ophthalmology & visual science · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. A short story on how chromophore is hydrolyzed from rhodopsin for recycling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Profile of Krzysztof Palczewski.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

John D HongGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.ORCID 0000-0002-5563-417X
David SalomGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.
Michał Andrzej KochmanInstitute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.
Adam KubasInstitute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.ORCID 0000-0002-5508-0533
Philip D KiserGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.ORCID 0000-0003-1184-9539
Krzysztof PalczewskiGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.ORCID 0000-0002-0788-545X
University of California, Irvine · USInstitute of Physical Chemistry · PL

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
The complex role of phosphodiesterase 6 in rod photoreceptor health and functionR01EY030873 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Krzysztof Palczewski · 2020 to 2026
$3.5M
Formation of Retinyl-Opsins by Retinyl Formate as Molecular Shades Against Light-Induced Retinal DamageF30EY033659 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HONG, JOHN DONG-HOON · 2022 to 2025
$195k
Retinoid cycles and retinal disease treatmentI01BX004939 · VA · VETERANS HEALTH ADMINISTRATION · PI KISER, PHILIP DAVID · 2020 to 2025
–
BLRD VA I01 BX004939HHS | National Institutes of Health (NIH) T32-GM08620HHS | NIH | National Eye Institute (NEI) 1F30EY033659-01HHS | NIH | National Eye Institute (NEI) EY030873NEI NIH HHS F30 EY033659NEI NIH HHS R01 EY030873NIGMS NIH HHS T32 GM008620
6 · The paper itself

Abstract

For sustained vision, photoactivated rhodopsin (Rho*) must undergo hydrolysis and release of all-

Indexed as

RetinaldehydeRhodopsinHydrolysisNADPPhosphatidylethanolaminesRetinoidsVitamin ANADPN-retinylidene-phosphatidylethanolaminePhosphatidylethanolaminesRetinaldehydeRetinoidsRhodopsinVitamin Achromophoreeyephotoreceptorsretinoidsrhodopsin

Identifiers

PMID36322748
PMCPMC9659404
OpenAlexW4308146446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.