Evidence map›Paper›PMID 36322726›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Spatial scale of tuberculosis transmission in Lima, Peru.

Chuan-Chin Huang, Letizia Trevisi, Mercedes C Becerra, Roger I Calderón, Carmen C Contreras, Judith Jimenez, Leonid W Lecca, Rosa M Yataco, Zibiao Zhang, Megan B Murray

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Quantifying the community transmission ofEmerging microbes & infections · 2026
    Article
  3. Article
  4. Article
  5. Genomic epidemiology ofMicrobial genomics · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Microbiological aspects and clinical impact of lower lung field tuberculosis: An observational cohort study in Peru.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
    Observational
  13. Observational
  14. Article
  15. Reply to CohenAmerican journal of respiratory and critical care medicine · 2024
    Article
  16. Who Transmits Tuberculosis to Whom: A Cross-Sectional Analysis of a Cohort Study in Lima, Peru.American journal of respiratory and critical care medicine · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Chuan-Chin HuangDepartment of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA 02115.
Letizia TrevisiDepartment of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA 02115.
Mercedes C BecerraDepartment of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA 02115.
Roger I CalderónSocios En Salud, Lima 15001, Peru.
Carmen C ContrerasSocios En Salud, Lima 15001, Peru.ORCID 0000-0001-6184-3819
Judith JimenezSocios En Salud, Lima 15001, Peru.ORCID 0000-0001-7633-8401
Leonid W LeccaDepartment of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA 02115.
Rosa M YatacoSocios En Salud, Lima 15001, Peru.
Zibiao ZhangDivision of Global Health Equity, Brigham and Women's Hospital, Boston, MA 02115.
Megan B MurrayDepartment of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA 02115.ORCID 0000-0003-0443-1986
Brigham and Women's Hospital · USEsSALUD · PEHarvard University · US

Funding

Sequencing CoreU19AI109755 · NIAID · HARVARD MEDICAL SCHOOL · PI CHANDLER, DARRELL P, CULHANE, AEDIN C · 2014 to 2018
$29.1M
Metabolomics Core U19AI111224 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH, MURRAY, MEGAN B · 2015 to 2021
$20.4M
Gerome Wide Association Study of Bacterial Determinants of Clinical Response in TuberculosisU19AI142793 · NIAID · HARVARD MEDICAL SCHOOL · PI MURRAY, MEGAN B · 2019 to 2023
$14.6M
Real-time surveillance to support dynamic and predictive models of MDR/XDR TBU19AI076217 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MURRAY, MEGAN B · 2007 to 2011
$13.5M
Epidemiology of multidrug-resistant tuberculosis in PeruU01AI057786 · NIAID · HARVARD MEDICAL SCHOOL · PI BECERRA, MERCEDES C · 2009 to 2010
$1.2M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01AI057786HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI076217HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI109755HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI111224NIAID NIH HHS U01 AI057786NIAID NIH HHS U19 AI076217NIAID NIH HHS U19 AI109755NIAID NIH HHS U19 AI111224NIAID NIH HHS U19 AI142793
6 · The paper itself

Abstract

Spatially targeted interventions may be effective alternatives to individual or population-based prevention strategies against tuberculosis (TB). However, their efficacy may depend on the mechanisms that lead to geographically constrained hotspots. Local TB incidence may reflect high levels of local transmission; conversely, they may point to frequent travel of community members to high-risk areas. We used whole-genome sequencing to explore patterns of TB incidence and transmission in Lima, Peru. Between 2009 and 2012, we recruited incident pulmonary TB patients and their household contacts, whom we followed for the occurrence of TB disease. We used whole-genome sequences of 2,712

Indexed as

Mycobacterium tuberculosisTuberculosisTuberculosis, PulmonaryHumansPeruWhole Genome Sequencinggenomic epidemiologyspatial analysistransmissiontuberculosiswhole-genome sequence

Identifiers

PMID36322726
PMCPMC9659349
OpenAlexW4308146828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.