Evidence map›Paper›PMID 36322725›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Rapid homeostatic modulation of transsynaptic nanocolumn rings.

Paola Muttathukunnel, Patrick Frei, Sarah Perry, Dion Dickman, Martin Müller

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Neto proteins differentially modulate the gating properties ofbioRxiv : the preprint server for biology · 2024
    Article
  12. Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Article
  16. Article
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  18. Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Paola MuttathukunnelDepartment of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-7023-2419
Patrick FreiDepartment of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.
Sarah PerryDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.
Dion DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089.ORCID 0000-0003-1884-284X
Martin MüllerDepartment of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0003-1624-6761
University of Zurich · CHUniversity of Southern California · US

Funding

Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
Synaptic Control of Glutamate HomeostasisR01NS111414 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2019 to 2023
$1.8M
NINDS NIH HHS R01 NS091546NINDS NIH HHS R01 NS111414
6 · The paper itself

Abstract

Robust neural information transfer relies on a delicate molecular nano-architecture of chemical synapses. Neurotransmitter release is controlled by a specific arrangement of proteins within presynaptic active zones. How the specific presynaptic molecular architecture relates to postsynaptic organization and how synaptic nano-architecture is transsynaptically regulated to enable stable synaptic transmission remain enigmatic. Using time-gated stimulated emission-depletion microscopy at the

Indexed as

Drosophila ProteinsNeuromuscular JunctionAnimalsDrosophilaMembrane ProteinsNeurotransmitter AgentsReceptors, GlutamateSynapsesSynaptic TransmissionDrosophila ProteinsMembrane ProteinsNeto protein, DrosophilaNeurotransmitter AgentsReceptors, Glutamateactive zoneDrosophilaglutamate receptorhomeostatic plasticitysynaptic nano-architecture

Identifiers

PMID36322725
PMCPMC9659372
OpenAlexW4308146264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.