Trial reportScience translational medicine2022
Selective decrease of donor-reactive T
Open access · greenAbstract readClinical Trial, Phase IIClinical Trial, Phase I
In one paragraph
Trial report in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 67 citations in OpenAlex.
- Donor-derived regulatory dendritic cell infusion and early immunosuppressive drug withdrawal in living-donor liver transplantation: a phase I/IIa trial.Nature communications · 2026Trial
- Pharmacokinetics, lineage identity, and trafficking of ex vivo expanded polyclonal regulatory T cells in a prospective randomized clinical trial of kidney transplant recipients with allograft inflammation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Trial
- Selective impact on regulatory T cells with sustained functional phenotypes by the interleukin-2 mutein VIS171 in a nonhuman primate model.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Clinical development of tacrolimus-resistant regulatory T cells to enable simultaneous immunosuppression and immune regulation.Molecular therapy. Advances · 2026Article
- Decoding TNF receptor superfamily control of CD4Cell communication and signaling : CCS · 2026Review
- Next-Generation regulatory T cell therapies: Translational considerations for inflammatory bowel disease.Human immunology · 2026Review
- Vortex-actuated pre-enrichment accelerates human regulatory T cell sorting and improves early fitness.Molecular therapy. Advances · 2026Article
- The Role of CD4Cells · 2026Review
- Cell Therapy in Advanced Cirrhosis: From Preclinical Evidence to Clinical Application.Gastro hep advances · 2026Review
- Postoperative Outcomes and Risk Profiles in Dual Liver-Lung Transplantation: A Single-Center Retrospective Analysis.Journal of transplantation · 2026Article
- Regulatory T cell therapies: biological foundations, engineering strategies, and clinical translation.Frontiers in immunology · 2026Review
- Regulatory T cell therapy in solid organ transplantation: mechanisms, translational progress, and remaining barriers.Frontiers in immunology · 2026Review
- Survival outcomes of patients after liver transplantation for patients with hepatocellular carcinoma exceeding the Hangzhou criteria.Journal of gastrointestinal oncology · 2025Article
- Lactic acid improves Treg manufacturing andMolecular therapy. Methods & clinical development · 2025Article
- Why regulatory T cells love lactic acid.Molecular therapy. Methods & clinical development · 2025Article
- Review
- Cellular Therapies in Transplantation - Regulatory T Cell Therapies and Virus Specific Therapies.Current transplantation reports · 2025Article
- HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model.Nature communications · 2025Article
- HLA-A2 CAR/IL-2-CISC engineered Treg display robustMolecular therapy. Methods & clinical development · 2025Article
- Regulatory T cell therapy in autoimmune liver disease and transplantation.JHEP reports : innovation in hepatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 9 institutions in 3 countries.
Qizhi TangDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-7313-3574
Joey LeungDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-2528-9555
Yani PengDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-3711-7160
Alberto Sanchez-FueyoInstitute of Liver Studies, School of Immunology and Microbial Sciences, King's College London University, London WC2R 2LS, UK.
Juan-Jose LozanoBioinformatic Platform, Biomedical Research Center in Hepatic and Digestive Diseases, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Alice LamDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Karim LeeDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
John R GreenlandDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-1422-8367
Marc HellersteinNutrition Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-2327-0834
Mark FitchNutrition Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-9058-4529
Kelvin W LiNutrition Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-1771-1998
Jonathan H EsenstenGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Amy L PutnamDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Angela LaresDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-8796-4627
Vinh NguyenDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Weihong LiuDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Nancy D BridgesNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.ORCID 0000-0002-1140-5201
Jonah OdimNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.ORCID 0000-0003-3465-8647
Anthony J DemetrisThomas E. Starzl Transplantation Institute and Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-9582-3733
Josh LevitskyDepartment of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-7527-6093
Timucin TanerDepartments of Surgery and Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Sandy FengDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-2601-4350
University of California, San Francisco · USUniversity of California, Berkeley · USGladstone Institutes · USNational Institute of Allergy and Infectious Diseases · USInstituto de Salud Carlos III · ESKing's College London · GBMayo Clinic · USNorthwestern University · USUniversity of Pittsburgh · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8MPolyclonal Tregs to Promote Tolerance in Pediatric Liver Transplant RecipientsU01AI104347 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FENG, SANDY · 2013 to 2017
$4.8MNIAID NIH HHS U01 AI104347NIDDK NIH HHS P30 DK063720
Abstract
Promoting immune tolerance to transplanted organs can minimize the amount of immunosuppressive drugs that patients need to take, reducing lifetime risks of mortality and morbidity. Regulatory T cells (T
Indexed as
Liver TransplantationTransplantation ToleranceGraft RejectionHumansLiving DonorsT-Lymphocytes, Regulatory
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.