Evidence map›Paper›PMID 36322363›Full record

ArticleNeurotoxicity research2022

Early Postnatal Exposure to Intermittent Hypercapnic Hypoxia (IHH), but Not Nicotine, Decreases Reelin in the Young Piglet Hippocampus.

Vanessa Despotovski, Arunnjah Vivekanandarajah, Karen A Waters, Rita Machaalani

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicity research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Reducing the risk of sudden unexpected infant death: the caffeine hypothesis.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vanessa DespotovskiDiscipline of Science, Life and Environmental Science, The University of Sydney, Camperdown, NSW, Australia.
Arunnjah VivekanandarajahDiscipline of Medicine, Central Clinical School, Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.
Karen A WatersDiscipline of Medicine, Central Clinical School, Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.ORCID http://orcid.org/0000-0001-8699-2175
Rita MachaalaniDiscipline of Medicine, Central Clinical School, Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia. rita.machaalani@sydney.edu.au.ORCID http://orcid.org/0000-0002-7675-1121
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the expression of reelin, an extracellular protein involved in lamination and migration of neurons, in the hippocampus of young piglets, and quantified to examine the following: (i) baseline levels within layers of the hippocampus and dentate gyrus (DG); (ii) differences between ventral and dorsal hippocampi; and (iii) changes attributable to postnatal exposure to continuous nicotine for 12 days, or intermittent hypercapnic hypoxia (IHH), with further analysis according to duration of IHH (1 vs 4 days). Additionally, we analysed whether any exposure altered DG morphology and whether it is related to altered reelin expression. Reelin was visualised via immunohistochemistry, and the number of positive reelin cells/mm

Indexed as

HippocampusNicotineAnimalsCell Adhesion Molecules, NeuronalDentate GyrusExtracellular Matrix ProteinsHypoxiaNeurogenesisNeuronsSwineCell Adhesion Molecules, NeuronalExtracellular Matrix ProteinsNicotineDentate gyrusDorsalGranule cell dispersionHippocampal formationSIDSVentral

Identifiers

PMID36322363
PMCPMC9797456
OpenAlexW4307965862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.