ArticleAging clinical and experimental research2023
Cognitive trajectories preluding the imminent onset of Alzheimer's disease dementia in individuals with normal cognition: results from the HELIAD cohort.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Is the 10-Year Trajectory of Physical Activity Associated With the Incidence of Mild Cognitive Impairment in Older Adults?Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Associations Between Cognitive Performance and Motor Signs in Older Adults with Alzheimer's Dementia.Medicina (Kaunas, Lithuania) · 2025Article
- Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia.Geriatrics (Basel, Switzerland) · 2025Article
- Motor signs and incident dementia with Lewy bodies in older adults with mild cognitive impairment.Journal of the American Geriatrics Society · 2025Article
- Tracking Cognitive Trajectories in Mild Cognitive Impairment Using a Machine Learning Technique of Subtype and Stage Inference.Dementia and neurocognitive disorders · 2025Article
- Conversion to Alzheimer's disease dementia from normal cognition directly or with the intermediate mild cognitive impairment stage.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Neuropsychiatric Symptoms Associated With Frontotemporal Atrophy in Older Adults Without Dementia.International journal of geriatric psychiatry · 2024Article
- Characterizing the progression from mild cognitive impairment to dementia: a network analysis of longitudinal clinical visits.BMC medical informatics and decision making · 2024Article
- Impact of distinct cognitive domains on gait variability in individuals with mild cognitive impairment and dementia.Experimental brain research · 2024Article
- Cognitive trajectories preluding the onset of different dementia entities: a descriptive longitudinal study using the NACC database.Aging clinical and experimental research · 2024Article
- Longitudinal Cognitive Trajectories in Older Adults with Restless Legs Syndrome or Willis-Ekbom Disease.Life (Basel, Switzerland) · 2024Article
- The Contribution of Functional Near-Infrared Spectroscopy (fNIRS) to the Study of Neurodegenerative Disorders: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Neuropsychiatric symptoms and incident Lewy body dementia in male versus female older adults with mild cognitive impairment.Psychiatry and clinical neurosciences · 2024Article
- Cognitive Performance and Incident Alzheimer's Dementia in Men Versus Women.The journal of prevention of Alzheimer's disease · 2024Article
- Article
- Investigating predictors of progression from mild cognitive impairment to Alzheimer's disease based on different time intervals.Age and ageing · 2023Article
- Associations between neuropsychiatric symptoms and incident Alzheimer's dementia in men versus women.Journal of neurology · 2023Article
- Comparison of DBFS with MoCA and MMSE tools for MCI screening.Bioinformation · 2023Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThe cognitive trajectories of cognitively normal (CN) individuals rapidly progressing to Alzheimer's disease dementia (AD) have not been investigated.
aimTo explore the preclinical pattern of cognitive performance heralding the rapid progression from normal cognition to AD.
methodsThe HELIAD cohort underwent comprehensive neuropsychological assessments (memory, language, attention, executive and visuo-perceptual functions) at baseline and after approximately 3-year intervals. The cognitive trajectories of those with normal cognition at baseline were explored according to the follow-up diagnosis using adjusted generalised estimating equations analyses.
resultsA total of 932 predominantly female (61%), older (72.9 ± 4.9), CN participants were followed for 3.09 (± 0.83) years. Among them, 761 individuals remained CN, 29 progressed to AD and 142 developed MCI (33 single-domain amnestic, 41 multidomain amnestic, 37 single-domain non-amnestic and 31 multidomain non-amnestic). Those progressing to AD were already performing worse than the healthy reference in every single cognitive domain at baseline. Cognitive deficits ranged between ~ 0.5SD (attention, executive function and language) and ~ 1.0SD (memory and visuo-perceptual skills). Throughout the 3-year follow-up, memory constantly exhibited the most prominent impairment compared to the remaining cognitive domains while executive function diminished in the most abrupt fashion (~ 0.19SD yearly) separating from the remaining three cognitive functions before the development of full-blown AD. Heterogeneous patterns of cognitive decline clearly differentiated those progressing to MCI from those rapidly converting to AD, as well. DISCUSSION: Poor performance in every cognitive domain may characterise cognitively normal individuals at high risk of fast progression to AD.
conclusionStrict neuropsychological cut-offs fail to detect a considerable number of individuals at high risk of rapid progression to AD.
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