Evidence map›Paper›PMID 36322308›Full record

ArticleBulletin of experimental biology and medicine2022

Hypermethylation of Long Non-Coding RNA Genes Group in the Breast Cancer Development and Progression.

A D Selezneva, E A Filippova, A D Selezneva, S S Lukina, I V Pronina, N A Ivanova, T P Kazubskaya, A M Burdennyy, E A Braga, V I Loginov

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

A D SeleznevaFaculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
E A FilippovaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
A D SeleznevaFaculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
S S LukinaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
I V ProninaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
N A IvanovaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
T P KazubskayaN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
A M BurdennyyResearch Institute of General Pathology and Pathophysiology, Moscow, Russia. burdennyy@gmail.com.
E A BragaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
V I LoginovResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RULomonosov Moscow State University · RUMinistry of Health of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed changes in the level of methylation of CpG islands in four long non-coding RNA (lncRNA) genes MEG3, ZNF667-AS1, GAS5, and SEMA3B-AS1 as promising markers of breast cancer. Methylation analysis was performed by quantitative methylation-specific PCR on a set of 38 paired (tumor/normal) breast cancer samples. Significantly (p<0.001) increased methylation was shown for three of the four lncRNA genes: MEG3, ZNF667-AS1, and SEMA3B-AS1. We found significant correlations of the methylation level of all the studied lncRNA genes with the stage of cancer and with lymphogenic metastasis, and for MEG3 and ZNF667-AS1 also with the tumor size. Methylation of ZNF667-AS1, and SEMA3B-AS1 genes in breast cancer was detected for the first time. Based on these findings, new potential markers for the diagnosis and prognosis of breast cancer can be proposed.

Indexed as

Breast NeoplasmsRNA, Long NoncodingCell Line, TumorCell ProliferationCpG IslandsDNA MethylationFemaleGene Expression Regulation, NeoplasticHumansRNA, Long Noncodingbreast cancergeneslong non-coding RNAsmethylation

Identifiers

PMID36322308
OpenAlexW4307970328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.