Evidence map›Paper›PMID 36322301›Full record

ArticleHepatology international2023

Predictive power of portal pressure gradient remeasured shortly after transjugular intrahepatic portosystemic shunt.

Li Ma, Jingqin Ma, Wen Zhang, Qingxin Liu, Zihan Zhang, Minjie Yang, Jiaze Yu, Xin Zhou, Shiyao Chen, Jian Wang and 2 more

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In one paragraph

Article in Hepatology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Li Ma *Shanghai Institution of Medical Imaging, Fudan University, Shanghai, China.
Jingqin Ma *Shanghai Institution of Medical Imaging, Fudan University, Shanghai, China.
Wen ZhangShanghai Institution of Medical Imaging, Fudan University, Shanghai, China.
Qingxin LiuShanghai Institution of Medical Imaging, Fudan University, Shanghai, China.
Zihan ZhangShanghai Institution of Medical Imaging, Fudan University, Shanghai, China.
Minjie YangShanghai Institution of Medical Imaging, Fudan University, Shanghai, China.
Jiaze YuShanghai Institution of Medical Imaging, Fudan University, Shanghai, China.
Xin ZhouShanghai Institution of Medical Imaging, Fudan University, Shanghai, China.
Shiyao ChenDepartment of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jian WangDepartment of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jianjun LuoShanghai Institution of Medical Imaging, Fudan University, Shanghai, China. luo.jianjun@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0003-4942-0439
Zhiping YanShanghai Institution of Medical Imaging, Fudan University, Shanghai, China. yan.zhiping@zs-hospital.sh.cn.
Fudan University · CNShanghai Medical College of Fudan University · CNSun Yat-sen University · CN

Funding

Clinical research special fund from Zhongshan Hospital, Fudan University 2018ZSLC23Excellent youth program from Zhongshan Hospital, Fudan University 2019ZSYXQN38National Clinical Research Center for Interventional Medicine 2021-001Shanghai key clinical specialty construction program W2019028
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe portal pressure gradient (PPG) measured at the time of transjugular intrahepatic portosystemic shunt (TIPS) completion (immediate PPG) is easily disturbed by many factors. This study aimed to assess the diagnostic value of PPG remeasured 2-4 days after TIPS (delayed PPG) by comparison with immediate PPG.

methodsWe retrospectively analyzed cirrhotic patients aged 18-75 years who received TIPS for preventing variceal rebleeding and pressure measurements at different time points.

resultsOf 154 eligible patients, 60 (39.0%), 62 (40.3%), and 32 (20.8%) were categorized into group LL (both immediate and delayed PPG < 12 mmHg), LH (immediate PPG < but delayed PPG ≥ 12 mmHg) and HH (both immediate and delayed PPG ≥ 12 mmHg), respectively. Mean immediate and delayed PPG were 9.2 mmHg and 12.8 mmHg (p < 0.001). During a median follow-up of 22 months, the 1-year probability of variceal rebleeding was significantly lower in group LL (1.7%) compared to LH (9.8%, absolute risk difference [ARD]: - 8.2%, p = 0.028) and HH (12.6%, ARD: - 11.1%, p = 0.014), but was not significantly different between groups LH and HH (ARD: - 2.9%, p = 0.671). Delayed PPG (p < 0.001) was identified as an independent predictor of variceal rebleeding in multivariable Cox regression analysis. The area under curves of delayed and immediate PPG in predicting variceal rebleeding were 0.837 and 0.693 for all patients (p = 0.031), and 0.936 and 0.694 for patients without shunt dysfunction (p < 0.001).

conclusionsIn cirrhotic patients with variceal bleeding, delayed PPG has higher predictive power for variceal rebleeding than immediate PPG.

Indexed as

Esophageal and Gastric VaricesPortasystemic Shunt, Transjugular IntrahepaticGastrointestinal HemorrhageHumansLiver CirrhosisPortal PressureRetrospective StudiesTreatment OutcomeCirrhosisHemodynamic readaptionLiverManometryPortal hypertensionPrognosisShunt dysfunctionVariceal rebleedingVaricesViral hepatitis

Identifiers

PMID36322301
OpenAlexW4307970539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.