SynthesisNeurosurgical review2022
Collagen-bound fibrin sealant (TachoSil®) for dural closure in cranial surgery: single-centre comparative cohort study and systematic review of the literature.
Synthesis in Neurosurgical review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Comparative analysis of the efficacy and safety of dural sealants in preventing complications after craniotomy: a systematic review and Bayesian network meta-analysis.Acta neurochirurgica · 2026Pooled it
- Comparative effectiveness of dural sealants versus conventional dural closure methods in cranial neurosurgery: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Cerebrospinal fluid leakage in patients after retrosigmoid approach for tumor resection: systematic review of techniques to manage dural closure and cranial reconstruction.Neurosurgical review · 2025Pooled it
- TachoSilNeurosurgical review · 2026Article
- Targeted repair of a refractory ventral cerebrospinal fluid leak identified by dynamic computed tomography myelography: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Efficacy of a synthetic collagen-based sealant (TachoSilNeurosurgical review · 2025Article
- The retrosigmoid keyhole approach to the cerebellopontine angle: a modified surgical technique and the evaluation of cerebrospinal fluid fistulas.Neurosurgical review · 2025Article
- Dura Closure Tactics to Prevent CSF Leakage in Microvascular Decompression Surgery.Life (Basel, Switzerland) · 2025Article
- The PEG-coated collagen patch Hemopatch® for hemostasis and dural sealing in neurosurgery.Frontiers in surgery · 2025Article
- Health and Economic Advantages Associated With the Use of TachoSil: An Update of Systematic Review.Therapeutics and clinical risk management · 2025Article
- Comparative evaluation of two dural closure techniques for U-shaped incisions: sealing efficacy vs. site-specific infection risk.Frontiers in surgery · 2025Article
- Diaphragm reconstruction using a TachoSil patch as alternative to intrasellar packing for small focal diaphragm defects in pituitary surgery: a cohort study.Acta neurochirurgica · 2024Article
- HemopatchNeurosciences (Riyadh, Saudi Arabia) · 2024Article
- Evaluating the Feasibility of Hydrogel-Based Neural Cell Sprays.Journal of functional biomaterials · 2023Article
- [Research status of dural injury types and repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Article
- Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebrospinal fluid (CSF) leakage is a well-known complication of craniotomies and there are several dural closure techniques. One commonly used commercial product as adjunct for dural closure is the collagen-bound fibrin sealant TachoSil®. We analysed whether the addition of TachoSil has beneficial effects on postoperative complications and outcomes. Our prospective, institutional database was retrospectively queried, and 662 patients undergoing craniotomy were included. Three hundred fifty-two were treated with dural suture alone, and in 310, TachoSil was added after primary suture. Our primary endpoint was the rate of postoperative complications associated with CSF leakage. Secondary endpoints included functional, disability and neurological outcome. Systematic review according to PRISMA guidelines was performed to identify studies comparing primary dural closure with and without additional sealants. Postoperative complications associated with CSF leakage occurred in 24 (7.74%) and 28 (7.95%) procedures with or without TachoSil, respectively (p = 0.960). Multivariate analysis confirmed no significant differences in complication rate between the two groups (aOR 0.97, 95% CI 0.53-1.80, p = 0.930). There were no significant disparities in postoperative functional, disability or neurological scores. The systematic review identified 661 and included 8 studies in the qualitative synthesis. None showed a significant superiority of additional sealants over standard technique regarding complications, rates of revision surgery or outcome. According to our findings, we summarize that routinary use of TachoSil and similar products as adjuncts to primary dural sutures after intracranial surgical procedures is safe but without clear advantage in complication avoidance or outcome. Future studies should investigate whether their use is beneficial in high-risk settings.
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