ArticleBehavior genetics2023
MR-DoC2: Bidirectional Causal Modeling with Instrumental Variables and Data from Relatives.
Article in Behavior genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- ADHD and Student Grades in Children from the ABCD StudyBehavior genetics · 2026Article
- Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.Molecular psychiatry · 2026Review
- Measurement Error and Power in Family-Based Extensions to Mendelian Randomization.Behavior genetics · 2025Article
- Prospective associations between major depressive disorder, generalized anxiety disorder, fibromyalgia, and myalgic encephalomyelitis/chronic fatigue syndrome.Psychological medicine · 2025Article
- Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study.BMC medicine · 2025Article
- Triangulated evidence provides no support for bidirectional causal pathways between diet/physical activity and depression/anxiety.Psychological medicine · 2025Article
- Unidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation.European journal of epidemiology · 2025Article
- Unidirectional and Bidirectional Causation between Smoking and Blood DNA Methylation: Evidence from Twin-based Mendelian Randomisation.medRxiv : the preprint server for health sciences · 2024Article
- A Note on Modelling Bidirectional Feedback Loops in Mendelian Randomization Studies.Behavior genetics · 2024Article
- Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins.BMC medicine · 2023Article
- Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins.medRxiv : the preprint server for health sciences · 2023Article
- Maximizing the value of twin studies in health and behaviour.Nature human behaviour · 2023Review
- Bidirectional Causal Associations Between Same-Sex Attraction and Psychological Distress: Testing Moderation and Mediation Effects.Behavior genetics · 2023Article
- Bullying Perpetration and Depressive Symptoms: A Causal Investigation of TwinLife Data.Clinical psychology & psychotherapyArticle
- Using Instrumental Variables to Measure Causation over Time in Cross-Lagged Panel Models.Multivariate behavioral researchArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Establishing causality is an essential step towards developing interventions for psychiatric disorders, substance use and many other conditions. While randomized controlled trials (RCTs) are considered the gold standard for causal inference, they are unethical in many scenarios. Mendelian randomization (MR) can be used in such cases, but importantly both RCTs and MR assume unidirectional causality. In this paper, we developed a new model, MRDoC2, that can be used to identify bidirectional causation in the presence of confounding due to both familial and non-familial sources. Our model extends the MRDoC model (Minică et al. in Behav Genet 48:337-349, https://doi.org/10.1007/s10519-018-9904-4 , 2018), by simultaneously including risk scores for each trait. Furthermore, the power to detect causal effects in MRDoC2 does not require the phenotypes to have different additive genetic or shared environmental sources of variance, as is the case in the direction of causation twin model (Heath et al. in Behav Genet 23:29-50, https://doi.org/10.1007/BF01067552 , 1993).
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Registered trials
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