Evidence map›Paper›PMID 36322172›Full record

ArticleThe Journal of membrane biology2023

Chloride Channel-3 (ClC-3) Modifies the Trafficking of Leucine-Rich Repeat-Containing 8A (LRRC8A) Anion Channels.

Ryan J Stark, Hong N Nguyen, Matthew K Bacon, Jeffrey C Rohrbough, Hyehun Choi, Fred S Lamb

Open access · greenAbstract read
In one paragraph

Article in The Journal of membrane biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. LRRC8A anion channels modulate vascular reactivity via association with myosin phosphatase rho interacting protein.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ryan J StarkDepartment of Pediatrics, Vanderbilt University Medical Center, 2215 Garland Avenue, Light Hall-1055D, Nashville, TN, 37232-3122v, USA.
Hong N NguyenDepartment of Pediatrics, Vanderbilt University Medical Center, 2215 Garland Avenue, Light Hall-1055D, Nashville, TN, 37232-3122v, USA.
Matthew K BaconDepartment of Pediatrics, University of Kentucky, Lexington, KY, 40536, USA.
Jeffrey C RohrboughDepartment of Pediatrics, Vanderbilt University Medical Center, 2215 Garland Avenue, Light Hall-1055D, Nashville, TN, 37232-3122v, USA.
Hyehun ChoiDepartment of Pediatrics, Vanderbilt University Medical Center, 2215 Garland Avenue, Light Hall-1055D, Nashville, TN, 37232-3122v, USA.
Fred S LambDepartment of Pediatrics, Vanderbilt University Medical Center, 2215 Garland Avenue, Light Hall-1055D, Nashville, TN, 37232-3122v, USA. fred.s.lamb@vanderbilt.edu.
Vanderbilt University Medical Center · USUniversity of Kentucky · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Anion channel regulation of vascular superoxide signaling in hypertensionR01HL160975 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LAMB, FRED S · 2022 to 2025
$2.9M
LRRC8 anion channels, superoxide and RhoA in diabetic erectile dysfunctionR01DK132948 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LAMB, FRED S, WEBB, R CLINTON · 2022 to 2025
$2.7M
Mechanisms of vascular dysfunction in acute systemic inflammationR35GM138191 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STARK, RYAN J · 2020 to 2024
$2.2M
NHLBI NIH HHS R01 HL160975NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK132948NIGMS NIH HHS R35 GM138191
6 · The paper itself

Abstract

Chloride channel-3 (ClC-3) Cl

Indexed as

Chloride ChannelsMembrane ProteinsAnionsHEK293 CellsHumansLeucineAnionsChloride ChannelsLeucineLRRC8A protein, humanMembrane ProteinsChloride Channel-3EndocytosisLeucine-rich repeat-containing protein 8AMultivesicular bodiesTrafficking

Identifiers

PMID36322172
PMCPMC10085862
OpenAlexW4307969826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.