Evidence map›Paper›PMID 36321845›Full record

ArticleBrain and behavior2022

Effects of acute high-altitude exposure on working memory: A functional near-infrared spectroscopy study.

Li Wang, Linqiong Sang, Yu Cui, Pengyue Li, Liang Qiao, Qiannan Wang, Wenqi Zhao, Qiu Hu, Najing Zhang, Ye Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. [Dynamic Effects of High-Altitude Exposure on Sleep and Mood States and the Underlying Neural Mechanisms].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Li WangKey Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Army Medical University, Chongqing, China.ORCID 0000-0001-7637-2378
Linqiong SangDepartment of Medical Imaging, College of Biomedical Engineering, Army Medical University, Chongqing, China.
Yu CuiDepartment of High Altitude Physiology and Pathology, College of High Altitude Military Medicine, Army Medical University, Chongqing, China.
Pengyue LiDepartment of Medical Imaging, College of Biomedical Engineering, Army Medical University, Chongqing, China.
Liang QiaoDepartment of Medical Imaging, College of Biomedical Engineering, Army Medical University, Chongqing, China.
Qiannan WangDepartment of Medical Imaging, College of Biomedical Engineering, Army Medical University, Chongqing, China.
Wenqi ZhaoKey Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Army Medical University, Chongqing, China.
Qiu HuKey Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Army Medical University, Chongqing, China.
Najing ZhangDepartment of Medical Imaging, College of Biomedical Engineering, Army Medical University, Chongqing, China.
Ye ZhangDepartment of Medical Imaging, College of Biomedical Engineering, Army Medical University, Chongqing, China.
Mingguo QiuDepartment of Medical Imaging, College of Biomedical Engineering, Army Medical University, Chongqing, China.
Jian ChenKey Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Army Medical University, Chongqing, China.
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInadequate oxygen availability may lead to impairment of neurocognitive functions. The aim of the present study was to investigate the effect of acute high-altitude exposure on the cerebral hemodynamic response and working memory.

methodsThe same subjects performed working memory exercises with forward and backward digit span tasks both under normal oxygen conditions and in large simulated hypobaric hypoxia chambers, and a series of physiological parameters were evaluated. Functional near-infrared spectroscopy was used to measure cerebral blood flow changes in the dorsolateral prefrontal cortex (DLPFC) during the tasks.

resultsCompared with normoxic conditions, under hypoxic conditions, the heart rate and blood pressure increased, blood oxygen saturation decreased significantly, and the forward task had similar accuracy and response time, while the backward task had lower accuracy and longer response time. Neuroimaging analysis showed increased activation in the DLPFC during the forward task and deactivation during the backward task under hypobaric hypoxia conditions.

conclusionAcute high-altitude exposure leads to physiological adaptations. The abnormal hemodynamic responses of the DLPFC to hypoxia at low pressure reveal the disruption of neurocognitive function by acute high-altitude exposure, which compromises complex cognitive functions, and provides a promising application for functional near infrared spectroscopy in the exploration of neural mechanisms in the brain during high-altitude exposure.

Indexed as

Memory, Short-TermSpectroscopy, Near-InfraredAltitudeHumansHypoxiaOxygenPrefrontal CortexOxygendorsolateral prefrontal cortex hemodynamic responsefNIRShigh altitudeworking memory

Identifiers

PMID36321845
PMCPMC9759148
OpenAlexW4307922142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.