Evidence map›Paper›PMID 36321828›Full record

ArticleEnvironmental health perspectives2022

Cardiac Development in the Presence of Cadmium: An

Xian Wu, Yichang Chen, Anthony Luz, Guang Hu, Erik J Tokar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Rethinking the microenvironment's role in chemical-induced malignancy.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Multiscale Construction, Evaluation, and Application of Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Advanced cardiac organoid model for studying doxorubicin-induced cardiotoxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Application of human cardiac organoids in cardiovascular disease research.Frontiers in cell and developmental biology · 2025
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Pluripotent stem cells for target organ developmental toxicity testing.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xian WuMechanistic Toxicology Branch, Division of the National Toxicology Program, National Institute for Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.ORCID 0000-0001-5710-5872
Yichang ChenMechanistic Toxicology Branch, Division of the National Toxicology Program, National Institute for Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.
Anthony LuzMechanistic Toxicology Branch, Division of the National Toxicology Program, National Institute for Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.
Guang HuEpigenetics and Stem Cell Biology Laboratory, Division of Intramural Research, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA.
Erik J TokarMechanistic Toxicology Branch, Division of the National Toxicology Program, National Institute for Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.ORCID 0000-0002-1668-2830

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExposure to cadmium (Cd) is associated with cardiovascular diseases. Maternal Cd exposure is a significant risk factor for congenital heart disease. However, mechanisms of Cd on developmental cardiotoxicity are not well defined.

objectivesWe evaluated the effects of Cd on the different stages (mesoderm, cardiac induction, cardiac function) of cardiac development using an early embryo development

methodsEmbryonic stem cells (ESCs) form 3D aggregates, called embryoid bodies, that recapitulate events involved with early embryogenesis (e.g., germ layer formation). This model was used for early germ layer formation and signaling pathway identification. The 2D cardiomyocyte differentiation from the

resultsCd ( DISCUSSION: In conclusion, using a human ESC-derived 2D/3D

Indexed as

Human Embryonic Stem CellsCadmiumCell DifferentiationHumansMyocytes, CardiacOrganoidsTranscription FactorsCadmiumTranscription Factors

Identifiers

PMID36321828
PMCPMC9628677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.