Evidence map›Paper›PMID 36321791›Full record

ArticleInternational journal of oncology2022

Realgar‑induced KRAS mutation lung cancer cell death via KRAS/Raf/MAPK mediates ferroptosis.

Xiaofeng Liu, Yang Hai, Jinqu Dong, Lan Xu, Wenqian Hou, Jing Su, Weiyu Ren, Dongling Liu

Open access · hybridAbstract read
In one paragraph

Article in International journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Role of Ferroptosis on Lung Epithelial Cells in Disease Progression and Treatment: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaofeng Liu *School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Yang Hai *Scientific Research and Experimental Center, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Jinqu DongSchool of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Lan XuSchool of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Wenqian HouSchool of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Jing SuSchool of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Weiyu RenSchool of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Dongling LiuSchool of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China.
Gansu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KRAS is a biomarker for non‑small cell lung cancer‑targeted therapy, but there is currently no effective KRAS‑targeting medication. Realgar is an impelling anticancer drug, however its significance in KRAS mutant lung cancer is uncertain. According to our findings, the IC

Indexed as

Carcinoma, Non-Small-Cell LungFerroptosisLung NeoplasmsApoptosisArsenicalsHumansMutationProto-Oncogene Proteins p21(ras)SorafenibSulfidesArsenicalsarsenic disulfideKRAS protein, humanProto-Oncogene Proteins p21(ras)SorafenibSulfidesapoptosisferroptosisKRAS‑mutantlung cancerrealgarSCL7A11

Identifiers

PMID36321791
PMCPMC9635866
OpenAlexW4307834056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.