Evidence map›Paper›PMID 36321614›Full record

ArticleJournal of public health (Oxford, England)2023

The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer-novel use of a large administrative database.

M J White, A C Sheka, C J LaRocca, R L Irey, S Ma, K M Wirth, A Benner, J W Denbo, E H Jensen, J S Ankeny and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of public health (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Pancreatic cancer in 2025: Have we found a solution?World journal of gastroenterology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Pancreatic Cancer: A Review of Risk Factors.Life (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

M J WhiteDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
A C ShekaDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
C J LaRoccaDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
R L IreyClinical and Translational Science Institute, University of Minnesota, Minneapolis MN, 55455 USA.
S MaClinical and Translational Science Institute, University of Minnesota, Minneapolis MN, 55455 USA.
K M WirthDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
A BennerClinical and Translational Science Institute, University of Minnesota, Minneapolis MN, 55455 USA.
J W DenboDepartment of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa FL 33612 USA.
E H JensenDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
J S AnkenyDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
S IkramuddinDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
T M TuttleDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
J Y C HuiDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
S MarmorDepartment of Surgery, University of Minnesota, Minneapolis MN, 55455 USA.
University of Minnesota · USMoffitt Cancer Center · USOptum (United States) · USSouthern California Clinical and Translational Science Institute · US

Funding

Training the Next Generation of Surgeon-Scientists in PancreatologyT32DK108733 · NIDDK · UNIVERSITY OF MINNESOTA · PI Srinath Chinnakotla, MASATO YAMAMOTO · 2017 to 2026
$1.4M
Hepatic Energy Fluxes, NASH, and Vertical Sleeve GastrectomyR21DK122832 · NIDDK · UNIVERSITY OF MINNESOTA · PI CRAWFORD, PETER A, IKRAMUDDIN, SAYEED · 2019 to 2020
$424k
NIDDK NIH HHS NIH/NIDDK R21 DK122832NIDDK NIH HHS T32 DK108733
6 · The paper itself

Abstract

backgroundScreening options for pancreatic ductal adenocarcinoma (PDAC) are limited. New-onset type 2 diabetes (NoD) is associated with subsequent diagnosis of PDAC in observational studies and may afford an opportunity for PDAC screening. We evaluated this association using a large administrative database.

methodsPatients were identified using claims data from the OptumLabs® Data Warehouse. Adult patients with NoD diagnosis were matched 1:3 with patients without NoD using age, sex and chronic obstructive pulmonary disease (COPD) status. The event of PDAC diagnosis was compared between cohorts using the Kaplan-Meier method. Factors associated with PDAC diagnosis were evaluated with Cox's proportional hazards modeling.

resultsWe identified 640 421 patients with NoD and included 1 921 263 controls. At 3 years, significantly more PDAC events were identified in the NoD group vs control group (579 vs 505; P < 0.001). When controlling for patient factors, NoD was significantly associated with elevated risk of PDAC (HR 3.474, 95% CI 3.082-3.920, P < 0.001). Other factors significantly associated with PDAC diagnosis were increasing age, increasing age among Black patients, and COPD diagnosis (P ≤ 0.05).

conclusionsNoD was independently associated with subsequent diagnosis of PDAC within 3 years. Future studies should evaluate the feasibility and benefit of PDAC screening in patients with NoD.

Indexed as

Carcinoma, Pancreatic DuctalDiabetes Mellitus, Type 2Pancreatic NeoplasmsAdultHumansRetrospective Studiescancerdiabetesscreening

Identifiers

PMID36321614
PMCPMC10273390
OpenAlexW4307976434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.