Evidence map›Paper›PMID 36321465›Full record

ArticleMedical physics2023

Modeling RBE with other quantities than LET significantly improves prediction of in vitro cell survival for proton therapy.

Fredrik Kalholm, Leszek Grzanka, Iuliana Toma-Dasu, Niels Bassler

Abstract read
In one paragraph

Article in Medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fredrik KalholmMedical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-6073-2700
Leszek GrzankaInstitute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland.ORCID https://orcid.org/0000-0002-3599-854X
Iuliana Toma-DasuMedical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7101-240X
Niels BasslerDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-4160-1078

Funding

Danish Cancer Society Research Center R191-A11526Danish Comprehensive Cancer CenterNovo Nordisk Fonden NNF195A0059372PLGrid Infrastructure plgccbmc9Radiumhemmets ForskningsfonderVetenskapsrådet
6 · The paper itself

Abstract

backgroundFor proton therapy, a relative biological effectiveness (RBE) of 1.1 has broadly been applied clinically. However, as unexpected toxicities have been observed by the end of the proton tracks, variable RBE models have been proposed. Typically, the dose-averaged linear energy transfer (LET PURPOSE: This study compares consistently calculated LET

methodsHigh-throughput experimental setups of in vitro cell survival studies for proton RBE determination are simulated using the SHIELD-HIT12A Monte Carlo particle transport code. Together with LET,

resultsVersions of Q

conclusionsThe study shows that Q or Q

Indexed as

Proton TherapyCell SurvivalLinear ModelsMonte Carlo MethodProtonsRelative Biological EffectivenessProtonsletproton RBE modelQ

Identifiers

PMID36321465
PMCPMC10134779

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.