ArticleDepression and anxiety2022
White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions.
Article in Depression and anxiety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- Glucocorticoid Dose and Type are Associated with Depression Scores in Youth with Classical Congenital Adrenal HyperplasiaJournal of clinical research in pediatric endocrinology · 2026Article
- Genome-wide association study of adolescent-onset depression.medRxiv : the preprint server for health sciences · 2025Article
- Identifying neurobiological markers as predictors of antidepressant treatment using diffusion tensor imaging: A tract-based spatial statistical analysis of cingulate bundle.CNS spectrums · 2025Article
- Fractional amplitude of low-frequency fluctuations in right dorsal cingulum bundle associated with depression symptoms in AD patients: effects of donepezil intervention.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.Psychiatry research. Neuroimaging · 2025Review
- Fractional Anisotropy of Cingulum Cingulate Mediates the Relationship Between Happiness and Work Performance in Healthy Individuals.Brain and behavior · 2025Article
- Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm.Neuroimage. Reports · 2024Article
- The Relationship between Neurobiological Function and Inflammation in Depressed Children and Adolescents: A Scoping Review.Neuropsychobiology · 2024Article
- Associations Between Socioeconomic Status, Obesity, Cognition, and White Matter Microstructure in Children.JAMA network open · 2023Article
- Associations between socioeconomic status and white matter microstructure in children: indirect effects via obesity and cognition.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
introductionCompared to research on adults with depression, relatively little work has examined white matter microstructure differences in depression arising earlier in life. Here we tested hypotheses about disruptions to white matter structure in adolescents with current and past depression, with an a priori focus on the cingulum bundles, uncinate fasciculi, corpus collosum, and superior longitudinal fasciculus.
methodsOne hundred thirty-one children from the Preschool Depression Study were assessed using a Human Connectome Project style diffusion imaging sequence which was processed with HCP pipelines and TRACULA to generate estimates of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD).
resultsWe found that reduced FA, reduced AD, and increased RD in the dorsal cingulum bundle were associated with a lifetime diagnosis of major depression and greater cumulative and current depression severity. Reduced FA, reduced AD, and increased RD in the ventral cingulum were associated with greater cumulative depression severity.
conclusionThese findings support the emergence of white matter differences detected in adolescence associated with earlier life and concurrent depression. They also highlight the importance of connections of the cingulate to other brain regions in association with depression, potentially relevant to understanding emotion dysregulation and functional connectivity differences in depression.
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