Evidence map›Paper›PMID 36321409›Full record

ArticleJournal of surgical oncology2023

Validating biologic age in selecting elderly patients with pancreatic cancer for surgical resection.

Anthony J Scholer, Rebecca Marcus, Mary Garland-Kledzik, Shu-Chin Chang, Adam Khader, Juan Santamaria-Barria, Zeljka Jutric, Ronald Wolf, Melanie Goldfarb

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Anthony J ScholerDivision of Surgical Oncology, University of South Carolina School of Medicine, Greenville, South Carolina, USA.ORCID http://orcid.org/0000-0002-7693-9298
Rebecca MarcusDepartment of Surgery, Saint John's Cancer Institute at Providence St. John's Health Center, Santa Monica, California, USA.
Mary Garland-KledzikDivision of Surgical Oncology, West Virginia University, Morgantown, West Virginia, USA.
Shu-Chin ChangDepartment of Surgery, Medical Data Research Center, Providence Saint Joseph Health, Oregon, Portland, USA.
Adam KhaderDepartment of Surgery, Division of Surgical Oncology, Hunter Holmes McGuire Veterans Affair Medical Center, Richmond, Virginia, USA.
Juan Santamaria-BarriaDepartment of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Zeljka JutricDepartment of Surgery, Division of Hepatobiliary and Pancreas Surgery and Islet Cell Transplantation, University of California Irvine Medical Center, Orange, California, USA.
Ronald WolfDepartment of Surgery, Division of Hepatobiliary and Pancreas Surgery and Islet Cell Transplantation, University of California Irvine Medical Center, Orange, California, USA.
Melanie GoldfarbDepartment of Surgery, Saint John's Cancer Institute at Providence St. John's Health Center, Santa Monica, California, USA.
Saint John's Health Center · USUniversity of California, Irvine Medical Center · USHunter Holmes McGuire VA Medical Center · USProvidence Saint Joseph Medical Center · USUniversity of Nebraska Medical Center · USUniversity of South Carolina · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSelecting frail elderly patients with pancreatic cancer (PC) for pancreas resection using biologic age has not been elucidated. This study determined the feasibility of the deficit accumulation frailty index (DAFI) in identifying such patients and its association with surgical outcomes.

methodsThe DAFI, which assesses frailty based on biologic age, was used to identify frail patients using clinical and health-related quality-of-life data. The characteristics of frail and nonfrail patients were compared.

resultsOf 242 patients (median age, 75.5 years), 61.2% were frail and 32.6% had undergone pancreas resection (surgery group). Median overall survival (mOS) decreased in frail patients (7.13 months, 95% confidence interval [CI]: 5.65-10.1) compared with nonfrail patients (16.1 months, 95% CI: 11.47-34.40, p = 0.001). In the surgery group, mOS improved in the nonfrail patients (49.4%; 49.2 months, 95% CI: 29.3-79.9) compared with frail patients (50.6%, 22.1 months, 95% CI: 18.3-52.4, p = 0.10). In the no-surgery group, mOS was better in nonfrail patients (54%; 10.81 months, CI 7.85-16.03) compared with frail patients (66%; 5.45 months, 95% CI: 4.34-7.03, p = 0.02).

conclusionsThe DAFI identified elderly patients with PC at risk of poor outcomes and can identify patients who can tolerate more aggressive treatments.

Indexed as

Biological ProductsFrailtyPancreatic NeoplasmsAgedFrail ElderlyGeriatric AssessmentHumansBiological Productsdeficit accumulation frailty indexdistal pancreatectomypancreas resectionwhipple

Identifiers

PMID36321409
PMCPMC10092356
OpenAlexW4307968190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.