ArticleAfrican health sciences2022
Twenty years of Prevention of Mother to Child HIV Transmission: research to implementation at a national referral hospital in Uganda.
Article in African health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Identifying individual, community and country-level determinants of poor knowledge of mother-to-child transmission of HIV among women in sub-Saharan Africa: spatial and multilevel analysis.SAGE open medicine · 2026Article
- Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review.African journal of primary health care & family medicine · 2025Article
- Global Maternal Child Health Initiatives and Programs 1974 to 2023.Maternal and child health journal · 2025Review
- An impact evaluation of the national prevention of mother to child HIV transmission program and MTCT associated factors in Uganda 2017-2019.Scientific reports · 2025Article
- Advancements and Challenges in Eliminating Perinatal Transmission of HIV in Sub-Saharan Africa: A Comprehensive Analysis.AIDS research and treatment · 2025Review
- Two Decades and Counting Since the Abuja Summit: Where Do We Stand in the Fight Against HIV/AIDS-Related Maternal Mortality?Women's health reports (New Rochelle, N.Y.) · 2025Article
- Correlates of early breastfeeding cessation and breastmilk expression in Uganda: a case-control study.The Journal of international medical research · 2024Article
- Scale-Up of HIV Antiretroviral Therapy and Estimation of Averted Infections and HIV-Related Deaths - Uganda, 2004-2022.MMWR. Morbidity and mortality weekly report · 2023Article
- A century of Makerere and 22 years of academic publishing: African Health Sciences into a new gear.African health sciences · 2022Article
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Authors and funding
9 authors.
Funding
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Abstract
Background: Over 90% of new paediatric HIV infections are acquired through mother to child transmission. Prevention of mother to child HIV transmission (PMTCT) research in sub-Saharan Africa informed WHO guidelines which enabled implementation of PMTCT programs globally. Objectives: To describe Makerere University-Johns Hopkins University (MU-JHU) perinatal HIV prevention research and implementation of the Mulago National Referral Hospital (MNRH) PMTCT program. Methods: Perinatal HIV prevention studies conducted at MU-JHU between 1997-2016 were summarized. Program aggregated data was extracted and analyzed using STATA 15. Results: In 1999, the HIVNET 012 study demonstrated that single-dose nevirapine (sdNVP) to the mother at onset of labor and to her newborn, reduced MTCT by nearly 50%. In 2016, the PROMISE study documented the safety and efficacy of ART during pregnancy and breastfeeding period. Program implementation at MNRH started in 2000. Uptake of HIV testing increased from 70% to 99% from 2006 onwards. sd NVP was the initial ARV regimen but by 2012, MOH recommended Option B+(triple therapy). MTCT rates reduced from 16.9% in 2001 to 2.3% in 2020. Conclusion: Perinatal HIV prevention clinical trials conducted at MU-JHU provided evidence to inform WHO PMTCT guidelines. MNRH program evaluation demonstrated the significant decline in MTCT rates over the last two decades.
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