Evidence map›Paper›PMID 36320916›Full record

ArticleChemical science2022

Palladium-peptide oxidative addition complexes for bioconjugation.

Anthony J Rojas, Justin M Wolfe, Heemal H Dhanjee, Ivan Buslov, Nicholas L Truex, Richard Y Liu, Walter Massefski, Bradley L Pentelute, Stephen L Buchwald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Not So Bioorthogonal Chemistry.Journal of the American Chemical Society · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Recent Advances in Bioorthogonal Ligation and Bioconjugation.Topics in current chemistry (Cham) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anthony J RojasDepartment of Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu sbuchwal@mit.edu.ORCID https://orcid.org/0000-0002-1975-7113
Justin M WolfeDepartment of Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu sbuchwal@mit.edu.
Heemal H DhanjeeDepartment of Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu sbuchwal@mit.edu.
Ivan BuslovDepartment of Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu sbuchwal@mit.edu.
Nicholas L TruexDepartment of Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu sbuchwal@mit.edu.
Richard Y LiuDepartment of Chemistry and Chemical Biology, Harvard University 12 Oxford Street Cambridge MA 02138 USA.
Walter MassefskiDepartment of Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu sbuchwal@mit.edu.
Bradley L PenteluteDepartment of Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu sbuchwal@mit.edu.ORCID https://orcid.org/0000-0002-7242-801X
Stephen L BuchwaldDepartment of Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA blp@mit.edu sbuchwal@mit.edu.ORCID https://orcid.org/0000-0003-3875-4775

Funding

Metal-Catalyzed Methods for Organic SynthesisR35GM122483 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI STEPHEN L BUCHWALD · 2017 to 2026
$11.4M
EARLY TRANSITION METAL CATALYSTS IN ORGANIC SYNTHESISR01GM046059 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BUCHWALD, STEPHEN L · 1992 to 2016
$5.4M
6 · The paper itself

Abstract

The synthesis of palladium oxidative addition complexes derived from unprotected peptides is described. Incorporation of 4-halophenylalanine into a peptide during solid phase peptide synthesis allows for subsequent oxidative addition at this position upon treatment with a palladium precursor and suitable ligand. The resulting palladium-peptide complexes are solid, storable, water-soluble, and easily purified

Identifiers

PMID36320916
PMCPMC9580489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.