Evidence map›Paper›PMID 36320888›Full record

ArticleRSC chemical biology2022

Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues.

John R D Hervey, Niklas Freund, Gillian Houlihan, Gurpreet Dhaliwal, Philipp Holliger, Alexander I Taylor

Abstract read
In one paragraph

Article in RSC chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Enzymatic Synthesis of Vancomycin-Modified DNA.Molecules (Basel, Switzerland) · 2022
    Article
  6. Thermophilic Nucleic Acid Polymerases and Their Application in Xenobiology.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John R D HerveyCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge Cambridge CB2 0AW UK ait29@cam.ac.uk.ORCID https://orcid.org/0000-0003-3176-5084
Niklas FreundMedical Research Council Laboratory of Molecular Biology Cambridge CB2 0QH UK ph1@mrc-lmb.cam.ac.uk.ORCID https://orcid.org/0000-0002-5622-9248
Gillian HoulihanMedical Research Council Laboratory of Molecular Biology Cambridge CB2 0QH UK ph1@mrc-lmb.cam.ac.uk.
Gurpreet DhaliwalCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge Cambridge CB2 0AW UK ait29@cam.ac.uk.
Philipp HolligerMedical Research Council Laboratory of Molecular Biology Cambridge CB2 0QH UK ph1@mrc-lmb.cam.ac.uk.ORCID https://orcid.org/0000-0002-3440-9854
Alexander I TaylorCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge Cambridge CB2 0AW UK ait29@cam.ac.uk.ORCID https://orcid.org/0000-0001-7684-1437

Funding

Medical Research Council MC_U105178804Wellcome Trust
6 · The paper itself

Abstract

Functional nucleic acids can be evolved

Identifiers

PMID36320888
PMCPMC9533476

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.