Evidence map›Paper›PMID 36320771›Full record

ArticleRSC advances2022

Enhancing the compatibility of BioCaRGOS silica sol-gel technology with ctDNA extraction and droplet digital PCR (ddPCR) analysis.

Chinmay S Potnis, Rajat Chauhan, Theodore S Kalbfleisch, Evan Alexander, Lindsay Eichhold, Meenakshi Bansal, Craig A Grapperhaus, Robert S Keynton, Mark W Linder, Gautam Gupta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chinmay S PotnisDepartment of Chemistry, University of Louisville Louisville 40292 Kentucky USA.ORCID https://orcid.org/0000-0002-6953-9106
Rajat ChauhanDepartment of Chemical Engineering, University of Louisville Louisville 40292 Kentucky USA gautam.gupta@louisville.edu.
Theodore S KalbfleischDepartment of Chemical Engineering, University of Louisville Louisville 40292 Kentucky USA gautam.gupta@louisville.edu.
Evan AlexanderDepartment of Pathology and Laboratory Medicine, University of Louisville Louisville 40292 Kentucky USA mark.linder@louisville.edu.
Lindsay EichholdDepartment of Chemical Engineering, University of Louisville Louisville 40292 Kentucky USA gautam.gupta@louisville.edu.
Meenakshi BansalDepartment of Chemistry, Thomas More University Crestview Hills KY 41017 USA.
Craig A GrapperhausDepartment of Chemistry, University of Louisville Louisville 40292 Kentucky USA.
Robert S KeyntonWilliam States Lee College of Engineering, University of North Carolina at Charlotte 28223 USA.
Mark W LinderDepartment of Pathology and Laboratory Medicine, University of Louisville Louisville 40292 Kentucky USA mark.linder@louisville.edu.
Gautam GuptaDepartment of Chemical Engineering, University of Louisville Louisville 40292 Kentucky USA gautam.gupta@louisville.edu.ORCID https://orcid.org/0000-0001-7607-4055

Funding

Supplement: Bio CaRGOS: Capture and release gels for optimized storage of Cancer BiospecimensR21CA251042 · NCI · UNIVERSITY OF LOUISVILLE · PI GUPTA, GAUTAM · 2020 to 2021
$584k
NCI NIH HHS R21 CA251042
6 · The paper itself

Abstract

Previously, our group had demonstrated long term stabilization of protein biomarkers using BioCaRGOS, a silica sol-gel technology. Herein, we describe workflow modifications to allow for extraction of cell free DNA (cfDNA) from primary samples containing working concentrations of BioCaRGOS, as well as the compatibility of BioCaRGOS with droplet digital PCR (ddPCR) analysis for pancreatic cancer biomarkers

Identifiers

PMID36320771
PMCPMC9557972

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.