ArticleHealth science reports2022
Endocrine hormone imbalance in heart failure with reduced ejection fraction: A cross-sectional study.
Article in Health science reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Interplay between parathyroid hormone concentration and valvular and aortic calcifications.Archives of medical science : AMS · 2026Article
- Sex Hormone-Binding Globulin and Cardiac Function in Men with Heart Failure: Possible Role of Diabetes.Journal of clinical medicine · 2025Article
- Is Low-free Triiodothyronine (fT3) Associated with Increased Morbidity in Patients Admitted to Coronary Care Units?Endocrine, metabolic & immune disorders drug targets · 2025Article
- Cardiovascular mechanisms of thyroid hormones and heart failure: Current knowledge and perspectives.World journal of cardiology · 2024Article
- Device therapies for heart failure with reduced ejection fraction: a new era.Frontiers in cardiovascular medicine · 2024Review
- Neurohumoral Activation in Heart Failure.International journal of molecular sciences · 2023Review
- Endocrine hormone imbalance in heart failure with reduced ejection fraction: A cross-sectional study.Health science reports · 2022Article
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Authors and funding
8 authors.
Funding
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Abstract
Background and Aims: Sustained neurohormonal activation plays a central role in the progression of heart failure (HF). Other endocrine axes may also be affected. It was the aim of this study to examine the endocrine profile (thyroid, parathyroid, glucocorticoid, and sex hormones) in a contemporary sample of patients with HF and reduced ejection fraction (EF) on established disease-modifying therapy. Methods: This study prospectively measured morning fasting hormones in 52 ambulatory and stable HF patients with EF < 50% on disease-modifying therapy (mean age 63 ± 11 years, 29% female, mean LVEF 32 ± 9.6%) and compared them to 54 patients at elevated risk for HF (61 ± 12 years, 28% female) and 62 healthy controls (HC; 61 ± 13 years, 27% female). Main comparisons were performed using one-way analysis of variance. Associations with biomarkers were studied with linear regression. Results: HF patients showed a reduced free triiodothyronine (fT3)/free thyroxine (fT4) ratio compared to HC (0.30 ± 0.06 vs. 0.33 ± 0.05, Conclusion: There is evidence of endocrine hormonal imbalance in HF with reduced EF beyond principal neurohormones and despite the use of disease-modifying therapy.
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