ArticleChemical science2022
A chemically fueled supramolecular glue for self-healing gels.
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Supramolecular Terbium-Threonine Chiral Emitters with Tunable Circularly Polarized Luminescence as Anticounterfeiting-Ink for Autonomous Data Encryption.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Kinetically programmed pathway-dependent autonomous reversibility in biomimetic self-assembly of nanoparticles.Chemical science · 2026Article
- Transient Salt-Bridge-Based Supramolecular Polymers: Experiments and Theory.Journal of the American Chemical Society · 2026Article
- Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel-Cell Interactions.Journal of the American Chemical Society · 2024Review
- Tuning the viscoelastic properties of peptide coacervates by single amino acid mutations and salt kosmotropicity.Communications chemistry · 2024Article
- Chemically Fueled Supramolecular Materials.Accounts of materials research · 2023Article
- AntibacterialInternational journal of molecular sciences · 2023Article
- Construction of transient supramolecular polymers controlled by mass transfer in biphasic systems.Chemical science · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemically fueled supramolecular materials offer unique properties that include spatial and temporal control and even the ability to self-heal. Indeed, a few studies have demonstrated the ability to self-heal, however, the underlying mechanisms remain unclear. Here, we designed a peptide that forms a fibrillar network upon chemical fueling. We were surprised that the hydrogel could self-heal despite the lack of dynamics in the fiber assembly and disassembly. We explain this behavior by a mechanism that involves the chemically fueled peptide molecules that cannot self-assemble due to the lack of nucleation sites. When the fibers are perturbed, new nucleation sites form that help the assembly resulting in the healing of the damaged network. Furthermore, we generalized the behavior for other peptides. We refer to this non-assembling, chemically-fueled peptide as a molecular glue. In future work, we aim to explore whether this self-healing mechanism applies to more complex structures, narrowing the gap between biological and synthetic self-assemblies.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.