ArticleChemical science2022
Atom and step economical synthesis of acyclic quaternary centers
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Umpolung Character of Styrenes: Mechanism and Stereoselective Studies of α, β-Substituted Amino Acids Using Chiral Ir-Phosphine Complexes.Journal of computational chemistry · 2026Article
- Ligand-Enabled Chemo- and Regioselective Ir(I)-Catalyzed Intermolecular Hydrocarbonation of Allenes: Access to Branched Products with All-Carbon Quaternary Centers.Angewandte Chemie (International ed. in English) · 2025Article
- The Discovery and Development of an Iridium-Catalyzed N→C Alkyl Transfer Reaction.Angewandte Chemie (International ed. in English) · 2025Article
- β-Quaternary α-Amino Acids via Iridium-Catalyzed Branched and Enantioselective Hydroalkylation of 1,1-Disubstituted Styrenes.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Quaternary benzylic centers are accessed with high atom and step economy by Ir-catalyzed alkene hydroarylation. These studies provide unique examples of the use of non-polarized 1,1-disubstituted alkenes in branch selective Murai-type hydro(hetero)arylations. Detailed mechanistic studies have been undertaken, and these indicate that the first irreversible step is the demanding alkene carbometallation process. Structure-reactivity studies show that the efficiency of this is critically dependent on key structural features of the ligand. Computational studies have been undertaken to rationalize this experimental data, showing how more sterically demanding ligands reduce the reaction barrier
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Registered trials
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