Evidence map›Paper›PMID 36320328›Full record

ArticleRSC medicinal chemistry2022

An organometallic analogue of combretastatin A-4 and its apoptosis-inducing effects on lymphoma, leukemia and other tumor cells

Liliane Abodo Onambele, Natalie Hoffmann, Lisa Kater, Lars Hemmersbach, Jörg-Martin Neudörfl, Nikolay Sitnikov, Benjamin Kater, Corazon Frias, Hans-Günther Schmalz, Aram Prokop

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In one paragraph

Article in RSC medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Comparison ofInorganica chimica acta · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liliane Abodo OnambeleDepartment of Pediatric Oncology/Hematology, Children's Hospital of the City of Cologne Amsterdamer Str. 59 50735 Cologne Germany.
Natalie HoffmannDepartment of Chemistry, University of Cologne Greinstrasse 4 50939 Cologne Germany schmalz@uni-koeln.de.
Lisa KaterDepartment of Pediatric Oncology/Hematology, University Medical Center Charité Campus Virchow, Augustenburger Pl. 1 13353 Berlin Germany.
Lars HemmersbachDepartment of Chemistry, University of Cologne Greinstrasse 4 50939 Cologne Germany schmalz@uni-koeln.de.
Jörg-Martin NeudörflDepartment of Chemistry, University of Cologne Greinstrasse 4 50939 Cologne Germany schmalz@uni-koeln.de.
Nikolay SitnikovDepartment of Chemistry, University of Cologne Greinstrasse 4 50939 Cologne Germany schmalz@uni-koeln.de.
Benjamin KaterDepartment of Pediatric Oncology/Hematology, University Medical Center Charité Campus Virchow, Augustenburger Pl. 1 13353 Berlin Germany.
Corazon FriasDepartment of Pediatric Oncology/Hematology, University Medical Center Charité Campus Virchow, Augustenburger Pl. 1 13353 Berlin Germany.
Hans-Günther SchmalzDepartment of Chemistry, University of Cologne Greinstrasse 4 50939 Cologne Germany schmalz@uni-koeln.de.ORCID https://orcid.org/0000-0003-0489-1827
Aram ProkopDepartment of Pediatric Oncology/Hematology, Children's Hospital of the City of Cologne Amsterdamer Str. 59 50735 Cologne Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hexacarbonyl[1,3-dimethoxy-5-((4'-methoxyphenyl)ethynyl)benzene]dicobalt (NAHO27), an organometallic analogue of combretastatin A-4, has been synthesized and its activity against lymphoma, leukemia, breast cancer and melanoma cells has been investigated. It was shown that NAHO27 specifically induces apoptosis in BJAB lymphoma and Nalm-6 leukemia cells at low micromolar concentration and does not affect normal leukocytes

Identifiers

PMID36320328
PMCPMC9491352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.